Chromosome Translocation
This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding...
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| Médium: | Elektronický zdroj E-kniha |
|---|---|
| Jazyk: | angličtina |
| Vydáno: |
Singapore :
Springer Singapore ,
2018.
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| Vydání: | 1st ed. 2018. |
| Edice: | Advances in Experimental Medicine and Biology,
1044 |
| Témata: | |
| ISBN: | 9789811305931 |
| ISSN: | 0065-2598 ; |
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Obsah:
- Chapter 1: Historical and clinical overview of chromosome translocations
- Chapter 2: Next generation sequencing to identify chromosome translocation
- Chapter 3: The experimental models to study chromosome translocations
- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome
- Chapter 5: Live cell imaging to study chromosome translocation
- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo
- Chapter 7: Generation of DNA double strand breaks (DSBs)
- Chapter 8: The role of DSB response pathway in regulating chromosome translocation
- Chapter 9: DSB repair and ligation of chromosome translocation
- Chapter 10: 3D genome organization defines the chromosome translocation pattern
- Chapter 11: Mechanisms of chromosome deletion
- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.