HIV-1 Latency
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and...
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| Médium: | Elektronický zdroj E-kniha |
|---|---|
| Jazyk: | angličtina |
| Vydáno: |
Cham :
Springer International Publishing,
2018.
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| Vydání: | 1st ed. 2018. |
| Edice: | Current Topics in Microbiology and Immunology,
417 |
| Témata: | |
| ISBN: | 9783030028169 |
| ISSN: | 0070-217X ; |
| On-line přístup: |
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| 020 | |a 9783030028169 | ||
| 024 | 7 | |a 10.1007/978-3-030-02816-9 |2 doi | |
| 035 | |a CVTIDW10097 | ||
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| 041 | |a eng | ||
| 245 | 1 | 0 | |a HIV-1 Latency |h [electronic resource] / |c edited by Guido Silvestri, Mathias Lichterfeld. |
| 250 | |a 1st ed. 2018. | ||
| 260 | 1 | |a Cham : |b Springer International Publishing, |c 2018. | |
| 300 | |a VII, 248 p. |b online resource. | ||
| 490 | 1 | |a Current Topics in Microbiology and Immunology, |x 0070-217X ; |v 417 | |
| 500 | |a Biomedical and Life Sciences | ||
| 505 | 0 | |a Molecular Control of HIV and SIV Latency -- Assays to Measure Latency, Reservoirs and Reactivation -- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir -- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy -- SIV Latency in Macrophages in the CNS -- Mathematical models of HIV latency -- Residual Immune Activation and Latency -- Immune Interventions to Eliminate the HIV Reservoir -- Cell and Gene Therapy for HIV Cure. | |
| 516 | |a text file PDF | ||
| 520 | |a This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public. | ||
| 650 | 0 | |a Immunology. | |
| 650 | 0 | |a Virology. | |
| 650 | 0 | |a Pathology. | |
| 650 | 0 | |a Epidemiology. | |
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