Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions

This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that c...

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Hlavný autor: Yan Shan, Ang (Autor)
Médium: Elektronický zdroj E-kniha
Jazyk:English
Vydavateľské údaje: Singapore : Springer Singapore , 2018.
Vydanie:1st ed. 2018.
Edícia:Springer Theses, Recognizing Outstanding Ph.D. Research,
Predmet:
Biochemical engineering.
Bioinformatics.
Nanotechnology.
Systems biology.
Biological systems.
ISBN:9789811321887
ISSN:2190-5053
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Obsah:
  • Introduction
  • Literature Review
  • Materials and Methods
  • Modular Framework for Engineering a Self-Contained DNA Circuit
  • Designing Hybridization Chain Reaction Monomers for Robust Signal Amplification
  • Design Concepts in Association Toehold for Robust Signal Transduction
  • DNA Split Proximity Circuit as a General Platform for Interrogating Biomolecular Events
  • DNA Split Proximity Circuit for Visualizing Cell Surface Receptor Clustering- A Case Study Using Human Epidermal Growth Factor Receptor Family
  • Conclusion and Future Outlooks.

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