Chemical Mixtures and Combined Chemical and Nonchemical Stressors Exposure, Toxicity, Analysis, and Risk /

Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are dis...

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Bibliographic Details
Format: Electronic eBook
Language:English
Published: Cham : Springer International Publishing, 2018.
Edition:1st ed. 2018.
Subjects:
Pharmacology.
Epidemiology.
Environmental health.
ISBN:9783319562346
Online Access: Get full text
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Table of Contents:
  • Introduction
  • Combined exposures.-Measuring combined exposures
  • Modeling complex exposures.-Prioritizing mixtures for study
  • Environment-Wide Association Studies
  • Biogeographical analysis of chemical co-occurrence
  • Combining exposure and toxicity information to develop logical groupings for assessment
  • Maximum Cumulative Ratio for deciding when to assess mixtures
  • Establishing the "no interaction" baseline
  • Dose addition models
  • Response addition
  • Integrated addition
  • Mixture statistics - comparing predicted to observed
  • Cumulative Risk Assessment
  • Deciding which approach to use
  • Component-based approaches
  • Sufficient similarity of whole mixtures
  • Other whole mixtures approaches
  • Assessing interactions
  • Likelihood and examples of chemical interactions
  • PBPK modeling of chemical interactions
  • Adding interactions to cumulative risk assessment
  • Consideration of nonchemical stressors
  • Toxicity and interactions of physical and chemical stressors
  • Psychosocial and chemical stressors
  • Adding nonchemical stressors to cumulative risk assessments
  • Disease-based risk assessment
  • Community-based risk assessment.

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