Drug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments /
Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on...
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| Médium: | Elektronický zdroj E-kniha |
|---|---|
| Jazyk: | angličtina |
| Vydáno: |
Cham :
Springer International Publishing,
2018.
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| Vydání: | 2nd ed. 2018. |
| Témata: | |
| ISBN: | 9783319741864 |
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Obsah:
- Prologue
- Introduction
- Part I Determinant features in Leishmaniasis
- Molecular evolution and phylogeny of Leishmania
- The role of reservoirs: canine Leishmaniasis
- Epidemiology of Leishmaniasis in the time of drug resistance
- The role of the immune system in resistance to infection
- Part II Challenges in the diagnosis, treatment and control of Leishmaniasis in the times of drug resistance
- Co-infection with HIV
- Visceral Leishmaniasis
- Tegumentary Leishmaniasis
- Antimony accounted sequel post Kala-Azar dermal Leishmaniasis
- Part III Molecular featrues of drug resistant Leishmania
- Genetic Expression and drug resistance, the role of proteomics
- The role of AMC transporters in drug-resistant Leishmania
- Functional analysis of Leishmania membrane (non AMC) transporters involved in drug resistance
- Part IV Pharmacology and chemotherapy of Leishmaniasis
- Classical vs. novel treatment regimens
- Bioinformatics in Leishmania drug design
- Leishmanis mitochondria, a druggable organelle
- P-glycoprotein-like transporters in Leishmania: a search for reversal agents
- Part V Strategies to circumvent drug resistance in Leishmania
- The relevance of susceptibility tests, breakpoints and markers
- The concept of fitness in Leishmania.