Development of Antibody-Based Therapeutics Translational Considerations & Challenges /

With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respec...

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Médium: Elektronický zdroj E-kniha
Jazyk:angličtina
Vydáno: Singapore : Springer Singapore, 2018.
Vydání:2nd ed. 2018.
Témata:
Pharmacy.
Pharmacology.
Biochemistry.
ISBN:9789811304965
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Obsah:
  • 1. Introduction
  • 2. Translational Considerations and Challenges: An Overview
  • 3. Considerations for Construct and Affinity Design Goals
  • 4. Epitope Characterization and Isotype Selection
  • 5. Biophysical Considerations for Development of Antibody-Based Therapeutics
  • 6. Novel Technologies for Generation of Bispecific Constructs
  • 7. Stimulus-Response Mechanisms: An Overview
  • 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models -A Quantitative Approach
  • 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities
  • 10. Antibody Drug Conjugates: Translational Considerations
  • 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs
  • 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.

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