Solubility in Pharmaceutical Chemistry /

This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify...

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Bibliographic Details
Other Authors: Nair, Anita (Editor), Saal, Christoph (Editor)
Format: eBook
Language:English
Published: Berlin ; Boston : De Gruyter, [2020]
©2020
Subjects:
Arzneimittel.
Formulierung.
Löslichkeit.
Wirkstofffreisetzung.
MEDICAL / Pharmacology.
farmaceutická chémia
elektronické dokumenty
ISBN:9783110559835
Online Access: Get full text
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Table of Contents:
  • Frontmatter
  • Contents
  • List of contributors
  • 1. Solubility - definition and basic physicochemical considerations
  • 2. Solubility and supersaturation
  • 3. In Silico methods to predict solubility
  • 4. How solubility influences bioavailability
  • 5. Estimation of intraluminal drug solubility
  • 6. Biorelevant media
  • 7. The role of solubility to optimize drug substances - a medicinal chemistry perspective
  • 8. The role of solubility in optimizing drug products - a pharmaceutical development perspective
  • 9. The relevance of solid-state forms for solubility
  • 10. Solubility and phase behaviour from a drug substance manufacturing perspective
  • 11. Biowaivers
  • List of Abbreviations
  • Index

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