A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analyti...
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| Format: | Electronic eBook |
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| Language: | English |
| Published: |
Cham :
Springer International Publishing,
2018.
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| Edition: | 1st ed. 2018. |
| Subjects: | |
| ISBN: | 9783319660844 |
| Online Access: |
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Table of Contents:
- 1. Introduction
- Part I: Biology
- 2. "Non-model" species for eco and human health risk assessment
- 3.The fish embryo as a model for eco-toxicology and other potential models
- 4.Invertebrates/Plants
- 5.Behavioral/Neurobehavioral linkages to AOPs
- 6. Species extrapolation - common pathways etc
- 7. Life History Evolution, incorporating evolutionary processes into AOPs to extrapolate
- Part II: Incorporating Biology into AOPs
- 8.Use of HTS assays to infer MIEs
- 9. AOP development: how to infer and define KER
- 10. The development of quantitative AOPs
- Part IV: Incorporating Modeling into AOPs.-11.Computational approaches (network science, etc) in AOPs: linking molecular datasets
- 12.Computational approaches : Dynamic Energy Budgets
- 13. Modeling approaches in AOPs: extrapolation from individual to population
- 14. Modeling approaches that augment AOPs: GUTS, QSAR, TKTD PBTKTD
- 15. Exposure science and other stressors? How to incorporate
- 16. AOP as an organizing framework and implications for biological science-AOP evolution
- 17. Use and acceptance of AOPs for regulatory applications, use of AOPs in human risk assessment, and legislation. .