Synthesis of Therapeutic Oligonucleotides

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleot...

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Bibliographische Detailangaben
Format: Elektronisch E-Book
Sprache:Englisch
Veröffentlicht: Singapore : Springer Singapore , 2018.
Ausgabe:1st ed. 2018.
Schlagworte:
Pharmaceutical technology.
Medicinal chemistry.
Molecular biology.
ISBN:9789811319129
Online-Zugang: Volltext
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Inhaltsangabe:
  • Part 1. Synthesis of Natural Oligonucleotides
  • Chapter 1. Non-protected Synthesis of Oligonucleotides
  • Chapter 2. Various Coupling Agents in the Phosphoramidite Method for Efficient Oligonucleotide Synthesis
  • Chapter 3. Recent Development of Chemical Synthesis of RNA
  • Chapter 4. RNA Synthesis Using the CEM Group
  • Chapter 5. Liquid-Phase Synthesis of Oligonucleotides
  • Chapter 6. Large-Scale Oligonucleotide Manufacturing
  • Part 2: Synthesis and Properties of Artificial Oligonucleotides
  • Chapter 1. Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modified Nucleobases
  • Chapter 2. Site-Specific Modification of nucleobases in oligonucleotides
  • Chapter 3. Four-Hydrogen-Bonding Base Pairs in Oligonucleotides: Design, Synthesis, and Properties
  • Chapter 4. Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Property of 3-Cyanovinylcarbazole-modified Nucleic Acids and Its Photo-induced Gene-Silencing Activity in Cells
  • Chapter 5. Effects of 2 ́-O-Modifications on RNA Duplex Stability
  • Chapter 6. 2',4'-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moiety
  • Chapter 7. Synthesis and Therapeutic Applications of Oligonucleotides Containing 2'-O,4'-C-Ethylene- and 3'-O,4'-C-Propylene-Bridged Nucleotides
  • Chapter 8. RNA Bioisosters: Chemistry and Properties of 4'-ThioRNA and 4'-SelenoRNA
  • Chapter 9. Development of Triplex Forming Oligonucleotide including Artificial Nucleoside Analogues for the Antigene Strategy
  • Chapter 10. Chemical Synthesis of Boranophosphate Deoxyribonucleotides.

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