Targeting Trafficking in Drug Development

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are exp...

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Bibliographische Detailangaben
Format: Elektronisch E-Book
Sprache:Englisch
Veröffentlicht: Cham : Springer International Publishing, 2018.
Ausgabe:1st ed. 2018.
Schriftenreihe:Handbook of Experimental Pharmacology, 245
Schlagworte:
Pharmacology.
Cell biology.
ISBN:9783319741642
ISSN:0171-2004 ;
Online-Zugang: Volltext
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Inhaltsangabe:
  • 1. Intracellular trafficking of gonadotropin receptors in health and disease
  • 2. Investigating internalization and intracellular trafficking of GPCRs
  • 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors
  • 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases
  • 5. Pharmacoperones for misfolded gonadotropin receptors
  • 6. Pharmacological chaperones: Beyond conformational disorders
  • 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer
  • 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches
  • 9. Conserved oligomeric Golgi and neuronal vesicular trafficking
  • 10. SLC6 transporter folding diseases and pharmacochaperoning
  • 11. The molecular physiopathogenesis of islet amyloidosis
  • 12. Folding defects leading to primary hyperoxaluria
  • 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .

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