Targeting Trafficking in Drug Development
Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are exp...
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| Médium: | Elektronický zdroj E-kniha |
|---|---|
| Jazyk: | angličtina |
| Vydáno: |
Cham :
Springer International Publishing,
2018.
|
| Vydání: | 1st ed. 2018. |
| Edice: | Handbook of Experimental Pharmacology,
245 |
| Témata: | |
| ISBN: | 9783319741642 |
| ISSN: | 0171-2004 ; |
| On-line přístup: |
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| 007 | cr nn 008mamaa | ||
| 008 | 180418s2018 gw | s |||| 0|eng d | ||
| 020 | |a 9783319741642 | ||
| 024 | 7 | |a 10.1007/978-3-319-74164-2 |2 doi | |
| 035 | |a CVTIDW14587 | ||
| 040 | |a Springer-Nature |b eng |c CVTISR |e AACR2 | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Targeting Trafficking in Drug Development |h [electronic resource] / |c edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao. |
| 250 | |a 1st ed. 2018. | ||
| 260 | 1 | |a Cham : |b Springer International Publishing, |c 2018. | |
| 300 | |a VIII, 425 p. 57 illus. |b online resource. | ||
| 490 | 1 | |a Handbook of Experimental Pharmacology, |x 0171-2004 ; |v 245 | |
| 500 | |a Biomedical and Life Sciences | ||
| 505 | 0 | |a 1. Intracellular trafficking of gonadotropin receptors in health and disease -- 2. Investigating internalization and intracellular trafficking of GPCRs -- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors -- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases -- 5. Pharmacoperones for misfolded gonadotropin receptors -- 6. Pharmacological chaperones: Beyond conformational disorders -- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer -- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches -- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking -- 10. SLC6 transporter folding diseases and pharmacochaperoning -- 11. The molecular physiopathogenesis of islet amyloidosis -- 12. Folding defects leading to primary hyperoxaluria -- 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. . | |
| 516 | |a text file PDF | ||
| 520 | |a Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding. | ||
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Cell biology. | |
| 856 | 4 | 0 | |u http://hanproxy.cvtisr.sk/han/cvti-ebook-springer-eisbn-978-3-319-74164-2 |y Vzdialený prístup pre registrovaných používateľov |
| 910 | |b ZE11867 | ||
| 919 | |a 978-3-319-74164-2 | ||
| 974 | |a andrea.lebedova |f Elektronické zdroje | ||
| 992 | |a SUD | ||
| 999 | |c 240424 |d 240424 | ||