Polycystic Kidney Disease Translating Mechanisms into Therapy /

This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focuse...

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Bibliographische Detailangaben
Format: Elektronisch E-Book
Sprache:Englisch
Veröffentlicht: New York, NY : Springer New York , 2018.
Ausgabe:1st ed. 2018.
Schlagworte:
Nephrology.
ISBN:9781493977840
Online-Zugang: Volltext
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Inhaltsangabe:
  • PART 1. POLYCYSTIC KIDNEY DISEASE GENES & PROTEINS
  • 1. Classical Polycystic Kidney Disease (PKD): Gene Structures and Mutations and Protein Structures and Functions
  • 2. Bardet-Biedl Syndrome
  • 3. Cystic Kidney Diseases Associated with Increased Cancer Risk: Tuberous Sclerosis Complex, Von Hippel Lindau, and Birt Hogg Dubé
  • PART 2. POLYCYCSTIC KIDNEY DISEASE: MECHANISMS OF DISEASE
  • 4. Aberrant Cellular Pathways in PKD
  • 5. Cilia and Polycystic Kidney Disease
  • 6. The Role of Inflammation and Fibrosis in Cystic Kidney Disease
  • PART 3. CLINICAL FEATURES
  • 7. Imaging-based Diagnosis of Autosomal Dominant Polycystic Kidney Disease
  • 8. Renal Structural Involvement in Autosomal Dominant Polycystic Kidney Disease: Cyst Growth and Total Kidney Volume: Lessons from the Consortium for Radiologic Imaging of Polycystic Kidney Disease (CRISP)
  • 9. Renal Complications: Pain, Infection and Nephrolithiasis
  • 10. ADPKD Extrarenal Manifestations: Polycystic Liver Disease
  • 11. Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease
  • PART 4. CLINICAL TRIALS AND EMERGING THERAPIES
  • 12. Role of Renin- Angiotensin- Aldosterone System Inhibition in Autosomal Dominant Polycystic Kidney Disease
  • 13. Vasopressin Receptor Antagonism
  • 14. End-stage Renal Disease in Patients with Autosomal Dominant Polycystic Kidney Disease
  • 15. Polycystic Kidney Disease: Translating Mechanisms into Therapy Management of ADPKD Today.

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