Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway...

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Hlavný autor: Bi, Yunchen (Autor)
Médium: Elektronický zdroj E-kniha
Jazyk:English
Vydavateľské údaje: Berlin, Heidelberg : Springer Berlin Heidelberg , 2018.
Vydanie:1st ed. 2018.
Edícia:Springer Theses, Recognizing Outstanding Ph.D. Research,
Predmet:
Biomedical engineering.
Biophysics.
Biological physics.
Cell membranes .
Immunology.
Atomic structure .
Molecular structure .
ISBN:9783662546185
ISSN:2190-5053
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Obsah:
  • Introduction
  • Review
  • Nanodisc assembly and the study on the interaction between the lipid and ion
  • Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation
  • The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin
  • Summary and prospect of this dissertation.

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