Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a ric...

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Bibliographische Detailangaben
1. Verfasser: Wong, Daniel Yuan Qiang (VerfasserIn)
Format: Elektronisch E-Book
Sprache:Englisch
Veröffentlicht: Singapore : Springer Singapore , 2018.
Ausgabe:1st ed. 2018.
Schriftenreihe:Springer Theses, Recognizing Outstanding Ph.D. Research,
Schlagworte:
Medicinal chemistry.
Medical biochemistry.
Cancer research.
ISBN:9789811085949
ISSN:2190-5053
Online-Zugang: Volltext
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Inhaltsangabe:
  • Introduction- Cisplatin- Now and Future
  • Harnessing Chemoselective Imine Ligation for Tethering Bioactive Molecules to Platinum (IV) Prodrugs
  • Probing the Platinum(IV) Prodrug Hypothesis - Are Platinum(IV) Complexes Really Prodrugs of Cisplatin?
  • Induction of Targeted Necrosis with HER2-Targeted Platinum(IV) Anticancer Prodrugs
  • Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents
  • Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes
  • Concluding Remarks.

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