Molecular Mechanisms of Notch Signaling

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular...

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Médium: Elektronický zdroj E-kniha
Jazyk:English
Vydavateľské údaje: Cham : Springer International Publishing, 2018.
Vydanie:1st ed. 2018.
Edícia:Advances in Experimental Medicine and Biology, 1066
Predmet:
Proteins .
ISBN:9783319895123
ISSN:0065-2598 ;
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Obsah:
  • Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis
  • Structural insights into Notch receptor-ligand interactions
  • The Molecular Mechanism of Notch Activation
  • Regulation of Notch Function by O-Glycosylation
  • Modeling the Notch response
  • Endocytic trafficking of the Notch receptor
  • The Notch Interactome: complexity in signaling circuitry
  • Integration of Drosophila and Human Genetics to understand Notch signaling related diseases
  • Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a Notch?
  • The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms
  • Notch and neurogenesis
  • Notch and stem cells
  • Oscillatory control of Notch signaling in development
  • CSL-associated corepressor and coactivator complexes
  • Notch and senescence
  • Control of blood vessel formation by Notch signaling
  • Notch and T cell function - a complex tale
  • Notch in leukemia.

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