Molecular Dynamics Analyses of Prion Protein Structures The Resistance to Prion Diseases Down Under /

Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational" diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for a...

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Bibliographische Detailangaben
1. Verfasser: Zhang, Jiapu (VerfasserIn)
Format: Elektronisch E-Book
Sprache:Englisch
Veröffentlicht: Singapore : Springer Singapore , 2018.
Ausgabe:1st ed. 2018.
Schriftenreihe:Focus on Structural Biology, 10
Schlagworte:
Proteomics.
ISBN:9789811088155
ISSN:1571-4853 ;
Online-Zugang: Volltext
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Inhaltsangabe:
  • Preface
  • Basic Knowledge
  • Part I Prion Resistance Species
  • Rabbits -Wild-type and Mutants
  • Dogs -Wild-type and D159NMutant
  • Horses, Buffaloes, and Pigs
  • Chicken, Turtles, and Frogs
  • Other Species
  • Part II b 2-a2 Loop
  • Wild-type Mouse 37 oC and 19.85 oC Structures
  • Mouse Mutants
  • Other Species with an Ordered b 2-a2
  • Part III Human Mutants
  • Human Mutants
  • Human PrPC Monomer, Dimer and Its M129V Mutant
  • Human Peptides
  • Part IV PrP Binding/Docking
  • PrP Bounded to Antibodies, Nanobody, RNA aptamer, etc
  • Potential Antiprion Drugs
  • Part V Prion Peptides with Cross-b Structures
  • Mathematical Formulas for All PrP Peptides' cross-b structures
  • Hydrogen Bonds Between Two Optimized Fundamental Chains of Each Model
  • References. .

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