Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considera...

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Bibliographische Detailangaben
1. Verfasser: Hirakawa, Akihiro (VerfasserIn)
Format: Elektronisch E-Book
Sprache:Englisch
Veröffentlicht: Tokyo : Springer Japan , 2018.
Ausgabe:1st ed. 2018.
Schriftenreihe:JSS Research Series in Statistics,
Schlagworte:
Statistics .
Biostatistics.
ISBN:9784431555735
ISSN:2364-0057
Online-Zugang: Volltext
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Inhaltsangabe:
  • 1. Introduction
  • 2. Phase I Trials for Drug Development in Oncology
  • 3. A Summary of Dose
  • Finding Methods in Standard Phase I Trials
  • 4. Phase I Trials for Combination of Two Agents
  • 5. Phase I Trials for Joint Assessment of Both Efficacy and Toxicity
  • 6. Additional Topics on Adaptive Dose
  • Finding Methods.

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