Innovations for Next-Generation Antibody-Drug Conjugates
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the i...
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| Médium: | Elektronický zdroj E-kniha |
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| Jazyk: | angličtina |
| Vydáno: |
Cham :
Springer International Publishing,
2018.
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| Vydání: | 1st ed. 2018. |
| Edice: | Cancer Drug Discovery and Development,
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| Témata: | |
| ISBN: | 9783319781549 |
| ISSN: | 2196-9906 |
| On-line přístup: |
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Obsah:
- Chapter 1 Introduction: Motivations for Next-Generation ADCs
- Chapter 2 Combining ADCs with Immuno-oncology Agents
- Chapter 3 Improving the Safety Profile of ADCs
- Chapter 4 Utility of PK-PD Modeling and Simulation to Improve Decision Making for Antibody-Drug Conjugate Development
- Chapter 5 Regulatory Considerations and Companion Diagnostics
- Chapter 6 ADC Process Development and Manufacturing
- Chapter 7 HER2-Targeted ADCs: At the forefront of ADC technology development
- Chapter 8 Next generation payloads for ADCs
- Chapter 9 Delivering more payload: High DAR ADCs
- Chapter 10 Site-Specific Antibody Drug Conjugates
- Chapter 11 Bispecific and Biparatopic Antibody-Drug Conjugates
- Chapter 12 drug conjugates to the tumor microenvironment: Probody Drug Conjugates
- Chapter 13 Antibody-Drug Conjugates: Targeting the Tumor Microenvironment
- Chapter 14 Next Horizons: ADCs Beyond Oncology.