TLR2 c.374C>T variant linked to natural resistance against brucellosis in Italian Mediterranean river buffalo.
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| Title: | TLR2 c.374C>T variant linked to natural resistance against brucellosis in Italian Mediterranean river buffalo. |
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| Authors: | Fulgione, Andrea1 (AUTHOR), Gentile, Antonio1 (AUTHOR), Iovane, Valentina1 (AUTHOR), Peretti, Vincenzo2 (AUTHOR), Montone, Angela Michela Immacolata3 (AUTHOR), Pauciullo, Alfredo4 (AUTHOR) alfredo.pauciullo@unito.it, Capparelli, Rosanna1 (AUTHOR) capparel@unina.it |
| Source: | BMC Veterinary Research. 10/21/2025, Vol. 21 Issue 1, p1-16. 16p. |
| Document Type: | Article |
| Subjects: | Brucellosis, Toll-like receptors, Immune response, Water buffalo, Natural immunity, Case-control method, Single nucleotide polymorphisms, Genomics |
| Geographic Terms: | Italy, Campania (Italy) |
| Author-Supplied Keywords: | Brucella abortus Computational analyses Genotyping Toll-like receptor 2 |
| Abstract: | Background: Brucellosis poses a significant threat to human health and the livestock industry, particularly affecting small-scale farmers. Several studies have demonstrated that TLR2 can recognize the Brucella abortus (B. abortus) surface lipoproteins (i.e. Omp10, Omp16 and Omp19), thus activating the immune response. This process can be altered by single nucleotide polymorphisms (SNPs) in TLR gene. This study aims to investigate whether the presence of SNPs in TLR2 could influence the resistance against brucellosis in Italian Mediterranean river buffalo, through case-control study and computational analysis. The study involved 194 Italian Mediterranean buffaloes, from three herds located in Caserta (Campania, Italy), grouped into 98 positive and 96 negative to brucellosis. Both groups, aged 40-90 months, were raised under similar environmental and management conditions to ensure consistency in the sampling. Results: The integration of association study with in silico analysis demonstrated that the c.374T, located in exon 2 of the TLR2 gene, could be associated with resistance to brucellosis (OR = 0.61; p-value = 0.037). Conclusions: This study highlights how TLRs genetic variations may influence protein activity and resistance to brucellosis. The genotyping analysis combined with in silico investigation could be considered an efficient approach for detecting possible candidate marker of resistance to buffalo brucellosis. [ABSTRACT FROM AUTHOR] |
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| Author Affiliations: | 1https://ror.org/05290cv24 Department of Agricultural Sciences, University of Naples Federico II, 80055, Portici, Italy 2https://ror.org/05290cv24 Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137, Naples, Italy 3https://ror.org/05r7f8853 Department of Food Inspection, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055, Portici, Italy 4https://ror.org/048tbm396 Department of Agriculture, Forest and Food Sciences, University of Torino, 10095, Grugliasco, Italy |
| Full Text Word Count: | 10623 |
| ISSN: | 1746-6148 |
| DOI: | 10.1186/s12917-025-05067-2 |
| Accession Number: | 188799057 |
| Database: | Veterinary Source |
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