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Novel Mutation Site in HOXD1 and RXFP2 Genes Detected in a Polycerated Garut Sheep (Ovis aries).

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Název: Novel Mutation Site in HOXD1 and RXFP2 Genes Detected in a Polycerated Garut Sheep (Ovis aries).
Autoři: Arifin, Johar1 (AUTHOR), Putra, Widya Pintaka Bayu2 (AUTHOR), Ridho, Muhammad3 (AUTHOR), Hartati, Hartati4 (AUTHOR), Handiwirawan, Eko4 (AUTHOR), Mariyono, Mariyono4 (AUTHOR) widy008@brin.go.id
Zdroj: Acta Veterinaria. Sep2025, Vol. 75 Issue 3, p429-436. 8p.
Druh dokumentu: Article
Témata: Homeobox genes, Genes, Heredity, Sheep, Indonesians, Point mutation (Biology)
Geografický termín: Jawa Barat (Indonesia)
Author-Supplied Keywords: Garut sheep
mutation
polyceraty
Abstrakt: Garut sheep (Ovis aries) is one of Indonesian native sheep breeds from West Java which is bred for meat production purposes. Despite this, Garut rams with good horn characteristic are also used for the fighting contest festival which is the famous cultural tradition in West Java. This study was aimed to detect the mutation site in the two functional genes controlling horn development i.e. HOXD1 and RXFP2. In this study, a rare polycerated (4 horns) Garut sheep was found at Cipacing Village, Sumedang Regency of West Java and used for investigation and compared with nine wildtype (2 horns) Garut sheep. Therefore, the partial sequences of HOXD1 (788 bp) and RXFP2 (505 bp) genes were amplified for the forward sequencing analysis. Results showed a presence of two novel mutations in the tested Garut sheep, namely g.742_743indel. TAAG in the HOXD1 gene and g.2218A>T in the RXFP2 gene. Specifically, a polycerated Garut sheep had the deletion 4 bp allele in HOXD1 gene and T allele of RXFP2 gene. In conclusion, horn characteristics of Garut sheep were controlled by novel mutation site in HOXD1 and RXFP2 genes. [ABSTRACT FROM AUTHOR]
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Author Affiliations: 1Padjadjaran University, Faculty of Animal Science, Sumedang, West Java 45363, Indonesia
2National Research and Innovation Agency, Research Center for Applied Zoology, Bogor, West Java 16911, Indonesia
3Universitas Sebelas Maret, Graduate student of Faculty of Animal Science, Surakarta, Central Java 57126, Indonesia
4National Research and Innovation Agency, Research Center for Animal Husbandry, Bogor, West Java 16911, Indonesia.
ISSN: 0567-8315
DOI: 10.2478/acve-2025-0033
Přístupové číslo: 188092521
Databáze: Veterinary Source
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  Data: Novel Mutation Site in HOXD1 and RXFP2 Genes Detected in a Polycerated Garut Sheep (Ovis aries).
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  Data: Garut sheep (Ovis aries) is one of Indonesian native sheep breeds from West Java which is bred for meat production purposes. Despite this, Garut rams with good horn characteristic are also used for the fighting contest festival which is the famous cultural tradition in West Java. This study was aimed to detect the mutation site in the two functional genes controlling horn development i.e. HOXD1 and RXFP2. In this study, a rare polycerated (4 horns) Garut sheep was found at Cipacing Village, Sumedang Regency of West Java and used for investigation and compared with nine wildtype (2 horns) Garut sheep. Therefore, the partial sequences of HOXD1 (788 bp) and RXFP2 (505 bp) genes were amplified for the forward sequencing analysis. Results showed a presence of two novel mutations in the tested Garut sheep, namely g.742_743indel. TAAG in the HOXD1 gene and g.2218A>T in the RXFP2 gene. Specifically, a polycerated Garut sheep had the deletion 4 bp allele in HOXD1 gene and T allele of RXFP2 gene. In conclusion, horn characteristics of Garut sheep were controlled by novel mutation site in HOXD1 and RXFP2 genes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Veterinaria is the property of Sciendo and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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