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Evaluation of lyophilized Tanacetum vulgare extract in intraruminal bolus and granule forms for gastrointestinal nematode control in sheep: An in vivo clinical study.

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Název: Evaluation of lyophilized Tanacetum vulgare extract in intraruminal bolus and granule forms for gastrointestinal nematode control in sheep: An in vivo clinical study.
Autoři: Vanaga, Aīda1 aida.vanaga@lbtu.lv, Keidāne, Dace2 dace.keidane@lbtu.lv, Kļaviņa, Alīna2 alina.klavina@lbtu.lv, Lūsis, Ivars2 ivars.lusis@lbtu.lv, Mālniece, Aija1 aija.malniece@lbtu.lv, Bandere, Dace3,4 dace.bandere@rsu.lv, Teterovska, Renāte3,4 renate.teterovska@rsu.lv, Bārzdiņa, Ance3,4 ance.barzdina@rsu.lv, Brante, Oxana3,4 oxana.brante@rsu.lv, Logviss, Konstantins3,4 konstantins.logviss@rsu.lv, Radziņš, Oskars3,4 oskars.radzins@rsu.lv, Kovaļčuka, Līga1 kovalcuka@gmail.com
Zdroj: Veterinary World. Jul2025, Vol. 18 Issue 7, p1991-2001. 11p.
Druh dokumentu: Article
Témata: Sheep, Antiparasitic agents, Herbaceous plants, Intestinal parasites, Phytotherapy, Drug delivery systems, Plant extracts, Powders
Author-Supplied Keywords: fecal egg count
gastrointestinal nematodes
intraruminal bolus
phytotherapy
sheep
Tanacetum vulgare
Abstrakt: Background and Aim: Gastrointestinal nematode infections have a significant impact on the health and productivity of sheep worldwide. Conventional anthelmintics are facing rising resistance, prompting the need for alternative control strategies. Tanacetum vulgare (tansy), a traditionally used antiparasitic herb in Latvia, has shown in vitro efficacy but lacks in vivo delivery validation. This study aimed to evaluate the in vivo antiparasitic efficacy and safety of T. vulgare extract administered through novel intraruminal boluses and granules in naturally infected sheep. Materials and Methods: Thirty female Latvian Darkhead lambs (4–5 months; mean 35 ± 0.8 kg) were randomly assigned to five groups: Two bolus groups (A and B), one granule group, and two controls (negative and positive). Groups A and B received intraruminal boluses with different lyophilized extract formulations, the granule group received powdered T. vulgare mixed with feed, and the positive control received levamisole. Fecal egg counts (FECs), clinical signs, and hematological and biochemical parameters were assessed over 56 days. Disintegration testing simulated rumen conditions. Results: No adverse clinical or physiological effects were observed. Bolus groups exhibited a more rapid and consistent reduction in strongylid FECs compared to the granule and negative control groups. On day 56, egg counts decreased to 325–358 eggs per gram (EPG) in bolus and granule groups, compared to 533 EPG in the negative control. Hematological and biochemical parameters remained within reference ranges. Conclusion: T. vulgare extract administered through intraruminal bolus was safe, sustained animal health, and effectively reduced gastrointestinal nematode burden. Granules were less effective, potentially due to reduced palatability. Bolus-based phytotherapy may serve as a sustainable, prophylactic alternative to conventional anthelmintics. [ABSTRACT FROM AUTHOR]
Copyright of Veterinary World is the property of Veterinary World and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Author Affiliations: 1Latvia University of Life Sciences and Technologies, Faculty of Veterinary Medicine, Clinical Institute, Jelgava, LV–3004, Latvia.
2Latvia University of Life Sciences and Technologies, Faculty of Veterinary Medicine, Institute of Food and Environmental Hygiene, Jelgava, LV–3004, Latvia.
3Riga Stradiņš University, Faculty of Pharmacy, Riga, LV-1007, Latvia.
4Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga LV-1048, Latvia.
ISSN: 0972-8988
DOI: 10.14202/vetworld.2025.1991-2001
Přístupové číslo: 187135250
Databáze: Veterinary Source
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  Data: Evaluation of lyophilized Tanacetum vulgare extract in intraruminal bolus and granule forms for gastrointestinal nematode control in sheep: An in vivo clinical study.
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  Data: <searchLink fieldCode="AR" term="%22Vanaga%2C+Aīda%22">Vanaga, Aīda</searchLink><relatesTo>1</relatesTo><i> aida.vanaga@lbtu.lv</i><br /><searchLink fieldCode="AR" term="%22Keidāne%2C+Dace%22">Keidāne, Dace</searchLink><relatesTo>2</relatesTo><i> dace.keidane@lbtu.lv</i><br /><searchLink fieldCode="AR" term="%22Kļaviņa%2C+Alīna%22">Kļaviņa, Alīna</searchLink><relatesTo>2</relatesTo><i> alina.klavina@lbtu.lv</i><br /><searchLink fieldCode="AR" term="%22Lūsis%2C+Ivars%22">Lūsis, Ivars</searchLink><relatesTo>2</relatesTo><i> ivars.lusis@lbtu.lv</i><br /><searchLink fieldCode="AR" term="%22Mālniece%2C+Aija%22">Mālniece, Aija</searchLink><relatesTo>1</relatesTo><i> aija.malniece@lbtu.lv</i><br /><searchLink fieldCode="AR" term="%22Bandere%2C+Dace%22">Bandere, Dace</searchLink><relatesTo>3,4</relatesTo><i> dace.bandere@rsu.lv</i><br /><searchLink fieldCode="AR" term="%22Teterovska%2C+Renāte%22">Teterovska, Renāte</searchLink><relatesTo>3,4</relatesTo><i> renate.teterovska@rsu.lv</i><br /><searchLink fieldCode="AR" term="%22Bārzdiņa%2C+Ance%22">Bārzdiņa, Ance</searchLink><relatesTo>3,4</relatesTo><i> ance.barzdina@rsu.lv</i><br /><searchLink fieldCode="AR" term="%22Brante%2C+Oxana%22">Brante, Oxana</searchLink><relatesTo>3,4</relatesTo><i> oxana.brante@rsu.lv</i><br /><searchLink fieldCode="AR" term="%22Logviss%2C+Konstantins%22">Logviss, Konstantins</searchLink><relatesTo>3,4</relatesTo><i> konstantins.logviss@rsu.lv</i><br /><searchLink fieldCode="AR" term="%22Radziņš%2C+Oskars%22">Radziņš, Oskars</searchLink><relatesTo>3,4</relatesTo><i> oskars.radzins@rsu.lv</i><br /><searchLink fieldCode="AR" term="%22Kovaļčuka%2C+Līga%22">Kovaļčuka, Līga</searchLink><relatesTo>1</relatesTo><i> kovalcuka@gmail.com</i>
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  Data: <searchLink fieldCode="DE" term="%22Sheep%22">Sheep</searchLink><br /><searchLink fieldCode="DE" term="%22Antiparasitic+agents%22">Antiparasitic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Herbaceous+plants%22">Herbaceous plants</searchLink><br /><searchLink fieldCode="DE" term="%22Intestinal+parasites%22">Intestinal parasites</searchLink><br /><searchLink fieldCode="DE" term="%22Phytotherapy%22">Phytotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+extracts%22">Plant extracts</searchLink><br /><searchLink fieldCode="DE" term="%22Powders%22">Powders</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22fecal+egg+count%22">fecal egg count</searchLink><br /><searchLink fieldCode="DE" term="%22gastrointestinal+nematodes%22">gastrointestinal nematodes</searchLink><br /><searchLink fieldCode="DE" term="%22intraruminal+bolus%22">intraruminal bolus</searchLink><br /><searchLink fieldCode="DE" term="%22phytotherapy%22">phytotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22sheep%22">sheep</searchLink><br /><searchLink fieldCode="DE" term="%22Tanacetum+vulgare%22">Tanacetum vulgare</searchLink>
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  Label: Abstract
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  Data: Background and Aim: Gastrointestinal nematode infections have a significant impact on the health and productivity of sheep worldwide. Conventional anthelmintics are facing rising resistance, prompting the need for alternative control strategies. Tanacetum vulgare (tansy), a traditionally used antiparasitic herb in Latvia, has shown in vitro efficacy but lacks in vivo delivery validation. This study aimed to evaluate the in vivo antiparasitic efficacy and safety of T. vulgare extract administered through novel intraruminal boluses and granules in naturally infected sheep. Materials and Methods: Thirty female Latvian Darkhead lambs (4–5 months; mean 35 ± 0.8 kg) were randomly assigned to five groups: Two bolus groups (A and B), one granule group, and two controls (negative and positive). Groups A and B received intraruminal boluses with different lyophilized extract formulations, the granule group received powdered T. vulgare mixed with feed, and the positive control received levamisole. Fecal egg counts (FECs), clinical signs, and hematological and biochemical parameters were assessed over 56 days. Disintegration testing simulated rumen conditions. Results: No adverse clinical or physiological effects were observed. Bolus groups exhibited a more rapid and consistent reduction in strongylid FECs compared to the granule and negative control groups. On day 56, egg counts decreased to 325–358 eggs per gram (EPG) in bolus and granule groups, compared to 533 EPG in the negative control. Hematological and biochemical parameters remained within reference ranges. Conclusion: T. vulgare extract administered through intraruminal bolus was safe, sustained animal health, and effectively reduced gastrointestinal nematode burden. Granules were less effective, potentially due to reduced palatability. Bolus-based phytotherapy may serve as a sustainable, prophylactic alternative to conventional anthelmintics. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Veterinary World is the property of Veterinary World and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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