Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective.
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| Název: | Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective. |
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| Autoři: | Dwi Agustin, Alfiana Laili1,2 alfiana.laili@gmail.com, Khairullah, Aswin Rafif3 aswinrafif@gmail.com, Effendi, Mustofa Helmi4 mhelmieffendi@gmail.com, Tyasningsih, Wiwiek5 wiwiek-t@fkh.unair.ac.id, Moses, Ikechukwu Benjamin6 ikechukwumoses937@gmail.com, Budiastuti, Budiastuti7 budiastuti@um-surabaya.ac.id, Plumeriastuti, Hani8 hani-p@fkh.unair.ac.id, Yanestria, Sheila Marty9 sheila.marty11.sm@gmail.com, Riwu, Katty Hendriana Priscilia2 kattyhpr@gmail.com, Eka Puji Dameanti, Fidi Nur Aini10 drhfidi@ub.ac.id, Wasito, Wasito3 wasi010@brin.go.id, Ahmad, Riza Zainuddin3 riza011@brin.go.id, Widodo, Agus11 agus.widodo@vokasi.unair.ac.id, Afnani, Daniah Ashri12 daniah.ashri@yahoo.co.id |
| Zdroj: | Veterinary World. May2025, Vol. 18 Issue 5, p1199-1213. 15p. |
| Druh dokumentu: | Literature Review |
| Témata: | Escherichia coli, Wildlife monitoring, Drug resistance in bacteria, Environmental health, Gene flow |
| Author-Supplied Keywords: | antibiotic resistance bats extended-spectrum β-lactamase guano One Health surveillance zoonosis |
| Abstrakt: | The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats, to the spread of antimicrobial resistance (AMR) remains underexplored. Bats possess unique ecological traits - such as long-distance flight, longevity, and adaptability - that facilitate their role as potential reservoirs and vectors of antibiotic-resistant bacteria. This review synthesizes global findings on the occurrence, genetic characteristics, and transmission dynamics of ESBL-producing E. coli isolated from bats. Through a comprehensive literature review of studies conducted across five continents, we highlight the prevalence of multidrug-resistant E. coli in bat populations, with resistance profiles frequently including β-lactams (bla), aminoglycosides, tetracyclines, and fluoroquinolones. Notably, key ESBL genes such as blaCTX-M, blaTEM, blaSHV, and blaOXA have been identified in isolates from bat feces (guano), raising significant concern due to potential environmental contamination and zoonotic spillover. Risk factors such as habitat encroachment, anthropogenic waste exposure, and the agricultural use of bat guano further exacerbate the risk of ESBL transmission. Moreover, genomic comparisons suggest phylogenetic overlap between ESBL-producing E. coli from bats and those found in humans and livestock. Given these findings, bats warrant greater inclusion in One Health surveillance frameworks to trace AMR gene flow and develop targeted interventions. This review underscores the need for integrated AMR monitoring in wildlife, enhanced waste management policies, and stricter biosecurity to mitigate the public health risks associated with wildlife-origin ESBL dissemination. [ABSTRACT FROM AUTHOR] |
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| Author Affiliations: | 1Doctoral Program of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia 2Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No. 59A, Dasan Agung Baru, Mataram, 83125, West Nusa Tenggara, Indonesia 3Research Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia 4Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia 5Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia 6Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, 480211, Nigeria 7Study Program of Pharmacy Science, Faculty of Health Science, Universitas Muhammadiyah Surabaya, Jl. Raya Sutorejo No.59, Dukuh Sutorejo, Mulyorejo, Surabaya, 60113, East Java, Indonesia 8Department of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia 9Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Jl. Dukuh Kupang XXV No.54, Dukuh Kupang, Dukuh Pakis, Surabaya, 60225, East Java, Indonesia 10Laboratory of Veterinary Microbiology and Immunology, Faculty of Veterinary Medicine, Universitas Brawijaya, Jl. Puncak Dieng, Kunci, Kalisongo, Dau, Malang, 65151, East Java, Indonesia 11Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jl. Dharmawangsa Dalam Selatan No. 28-30, Kampus B Airlangga, Surabaya, 60115, East Java, Indonesia 12Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No. 59A, Dasan Agung Baru, Mataram, 83125, West Nusa Tenggara, Indonesia |
| ISSN: | 0972-8988 |
| DOI: | 10.14202/vetworld.2025.1199-1213 |
| Přístupové číslo: | 185668362 |
| Databáze: | Veterinary Source |
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