Prevalence and risk factors associated with nasal carriage of methicillin-resistant staphylococci in horses and their caregivers.
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| Titel: | Prevalence and risk factors associated with nasal carriage of methicillin-resistant staphylococci in horses and their caregivers. |
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| Autoren: | Bullone, Michela1 (AUTHOR) michela.bullone@unito.it, Bellato, Alessandro1 (AUTHOR), Robino, Patrizia1 (AUTHOR), Nebbia, Patrizia1 (AUTHOR), Morello, Sara2 (AUTHOR), Marchis, Daniela2 (AUTHOR), Tarducci, Alberto1 (AUTHOR), Ru, Giuseppe3 (AUTHOR) |
| Quelle: | Veterinary Research. 9/9/2024, Vol. 55 Issue 1, p1-11. 11p. |
| Publikationsart: | Article |
| Schlagworte: | Poisson regression, Horse industry, Race horses, Drug resistance in microorganisms, Bacterial communities |
| Author-Supplied Keywords: | AMR genes antimicrobial resistance Horse methicillin-resistant staphylococci (MRS) nasal carriage risk factors |
| Abstract: | Antimicrobial resistance is a global threat, and pet-associated strains may pose a risk to human health. Equine veterinarians are at high risk of carrying methicillin-resistant staphylococci (MRS), but specific risk factors remain elusive, and few data are available for other personnel involved in the horse industry. The prevalence, characteristics, and risk factors for nasal carriage of MRS in horses and their caregivers were studied in northwestern Italy. Nasal swabs from 110 asymptomatic horses housed at 21 barns and 34 human caregivers were collected. Data on barns, horses, and personnel were acquired through questionnaires. The samples were incubated in selective media, and the bacterial isolates were identified by mass spectrometry. Risk factors were investigated by Poisson regression. MRS were isolated from 33 horses (30%), 11 humans (32.4%) and 3 environmental samples (14.2%). Most isolates were multidrug resistant (MDRS). The prevalence of MRS and MDRS was greater in racehorses and their personnel than in pleasurable and jumping/dressing horses. MRS carriage in caregivers was associated with an increased prevalence of MRS carriage in horses. The frequency of antimicrobial treatments administered in the barn during the last 12 months was a risk factor for MRS carriage in horses [prevalence ratio (PR) 3.97, 95% CI 1.11, 14.13] and caregivers (PR 2.00, 95% CI 1.05, 3.82), whereas a good ventilation index of the horse tabling environment was a protective factor (PR 0.43, 95% CI 0.20, 0.92). Our data reveal relevant interactions occurring between bacterial communities of horses and humans that share the same environment, suggesting that One Health surveillance programs should be implemented. [ABSTRACT FROM AUTHOR] |
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| Author Affiliations: | 1https://ror.org/048tbm396 Department of Veterinary Sciences, University of Torino, Largo Paolo Braccini 2, 10095, Grugliasco, Italy 2Feed Hygiene Laboratory, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, via Bologna 148, 10154, Torino, Italy 3Biostatistics, Epidemiology and Risk Analysis Unit, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, via Bologna 220, 10154, Torino, Italy |
| Full Text Word Count: | 8995 |
| ISSN: | 0928-4249 |
| DOI: | 10.1186/s13567-024-01364-0 |
| Dokumentencode: | 179534512 |
| Datenbank: | Veterinary Source |
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| Abstract: | Antimicrobial resistance is a global threat, and pet-associated strains may pose a risk to human health. Equine veterinarians are at high risk of carrying methicillin-resistant staphylococci (MRS), but specific risk factors remain elusive, and few data are available for other personnel involved in the horse industry. The prevalence, characteristics, and risk factors for nasal carriage of MRS in horses and their caregivers were studied in northwestern Italy. Nasal swabs from 110 asymptomatic horses housed at 21 barns and 34 human caregivers were collected. Data on barns, horses, and personnel were acquired through questionnaires. The samples were incubated in selective media, and the bacterial isolates were identified by mass spectrometry. Risk factors were investigated by Poisson regression. MRS were isolated from 33 horses (30%), 11 humans (32.4%) and 3 environmental samples (14.2%). Most isolates were multidrug resistant (MDRS). The prevalence of MRS and MDRS was greater in racehorses and their personnel than in pleasurable and jumping/dressing horses. MRS carriage in caregivers was associated with an increased prevalence of MRS carriage in horses. The frequency of antimicrobial treatments administered in the barn during the last 12 months was a risk factor for MRS carriage in horses [prevalence ratio (PR) 3.97, 95% CI 1.11, 14.13] and caregivers (PR 2.00, 95% CI 1.05, 3.82), whereas a good ventilation index of the horse tabling environment was a protective factor (PR 0.43, 95% CI 0.20, 0.92). Our data reveal relevant interactions occurring between bacterial communities of horses and humans that share the same environment, suggesting that One Health surveillance programs should be implemented. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09284249 |
| DOI: | 10.1186/s13567-024-01364-0 |