Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology.
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| Název: | Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology. |
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| Autoři: | London, Cheryl A.1 (AUTHOR) cheryl.london@tufts.edu, Gardner, Heather1 (AUTHOR), Zhao, Shaying2 (AUTHOR), Knapp, Deborah W.3 (AUTHOR), Utturkar, Sagar M.4 (AUTHOR), Duval, Dawn L.5 (AUTHOR), Chambers, Melissa R.6 (AUTHOR), Ostrander, Elaine7 (AUTHOR), Trent, Jeffrey M.8 (AUTHOR), Kuffel, Gina9 (AUTHOR) |
| Zdroj: | Veterinary & Comparative Oncology. Dec2023, Vol. 21 Issue 4, p565-577. 13p. |
| Druh dokumentu: | Article |
| Témata: | Genomics, Human biology, Best practices, Oncology, Dogs |
| Author-Supplied Keywords: | canine genome data analysis tumour genomics |
| Abstrakt: | Pet dogs develop spontaneous cancers at a rate estimated to be five times higher than that of humans, providing a unique opportunity to study disease biology and evaluate novel therapeutic strategies in a model system that possesses an intact immune system and mirrors key aspects of human cancer biology. Despite decades of interest, effective utilization of pet dog cancers has been hindered by a limited repertoire of necessary cellular and molecular reagents for both in vitro and in vivo studies, as well as a dearth of information regarding the genomic landscape of these cancers. Recently, many of these critical gaps have been addressed through the generation of a highly annotated canine reference genome, the creation of several tools necessary for multi‐omic analysis of canine tumours, and the development of a centralized repository for key genomic and associated clinical information from canine cancer patients, the Integrated Canine Data Commons. Together, these advances have catalysed multidisciplinary efforts designed to integrate the study of pet dog cancers more effectively into the translational continuum, with the ultimate goal of improving human outcomes. The current review summarizes this recent progress and provides a guide to resources and tools available for comparative study of pet dog cancers. [ABSTRACT FROM AUTHOR] |
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| Author Affiliations: | 1Cummings School of Veterinary Medicine, Tufts University, North Grafton Massachusetts,, USA 2University of Georgia Cancer Center, University of Georgia, Athens Georgia,, USA 3College of Veterinary Medicine, Purdue University, West Lafayette Indiana,, USA 4Purdue Institute for Cancer Research, Purdue University, West Lafayette Indiana,, USA 5College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins Colorado,, USA 6School of Medicine, University of Alabama, Birmingham Alabama,, USA 7Cancer Genetics and Comparative Genomics Branch, National Cancer Institute, Bethesda Maryland,, USA 8Translational Genomics Research Institute, Phoenix Arizona,, USA 9National Human Genome Research Institute, National Institutes of Health, Bethesda Maryland,, USA |
| ISSN: | 1476-5810 |
| DOI: | 10.1111/vco.12935 |
| Přístupové číslo: | 173660894 |
| Databáze: | Veterinary Source |
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