Metabolic Engineering of Yeast
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| Název: | Metabolic Engineering of Yeast |
|---|---|
| Autoři: | Shi, Shuobo, 1981, Chen, Yu, Nielsen, Jens B, 1962 |
| Zdroj: | Annual review of biophysics. 54(1):101-120 |
| Témata: | yeast cell factory, synthetic biology, computational design, Saccharomyces cerevisiae, biorefinery, metabolic engineering |
| Popis: | Microbial cell factories have been developed to produce various compounds in a sustainable and economically viable manner. The yeast Saccharomyces cerevisiae has been used as a platform cell factory in industrial biotechnology with numerous advantages, including ease of operation, rapid growth, and tolerance for various industrial stressors. Advances in synthetic biology and metabolic models have accelerated the design-build-test-learn cycle in metabolic engineering, significantly facilitating the development of yeast strains with complex phenotypes, including the redirection of metabolic fluxes to desired products, the expansion of the spectrum of usable substrates, and the improvement of the physiological properties of strain. Strains with enhanced titer, rate, and yield are now competing with traditional petroleum-based industrial approaches. This review highlights recent advances and perspectives in the metabolic engineering of yeasts for the production of a variety of compounds, including fuels, chemicals, proteins, and peptides, as well as advancements in synthetic biology tools and mathematical modeling. |
| Popis souboru: | electronic |
| Přístupová URL adresa: | https://research.chalmers.se/publication/546527 https://research.chalmers.se/publication/546527/file/546527_Fulltext.pdf |
| Databáze: | SwePub |
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| Items | – Name: Title Label: Title Group: Ti Data: Metabolic Engineering of Yeast – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shi%2C+Shuobo%22">Shi, Shuobo</searchLink>, 1981<br /><searchLink fieldCode="AR" term="%22Chen%2C+Yu%22">Chen, Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Nielsen%2C+Jens+B%22">Nielsen, Jens B</searchLink>, 1962 – Name: TitleSource Label: Source Group: Src Data: <i>Annual review of biophysics</i>. 54(1):101-120 – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22yeast+cell+factory%22">yeast cell factory</searchLink><br /><searchLink fieldCode="DE" term="%22synthetic+biology%22">synthetic biology</searchLink><br /><searchLink fieldCode="DE" term="%22computational+design%22">computational design</searchLink><br /><searchLink fieldCode="DE" term="%22Saccharomyces+cerevisiae%22">Saccharomyces cerevisiae</searchLink><br /><searchLink fieldCode="DE" term="%22biorefinery%22">biorefinery</searchLink><br /><searchLink fieldCode="DE" term="%22metabolic+engineering%22">metabolic engineering</searchLink> – Name: Abstract Label: Description Group: Ab Data: Microbial cell factories have been developed to produce various compounds in a sustainable and economically viable manner. The yeast Saccharomyces cerevisiae has been used as a platform cell factory in industrial biotechnology with numerous advantages, including ease of operation, rapid growth, and tolerance for various industrial stressors. Advances in synthetic biology and metabolic models have accelerated the design-build-test-learn cycle in metabolic engineering, significantly facilitating the development of yeast strains with complex phenotypes, including the redirection of metabolic fluxes to desired products, the expansion of the spectrum of usable substrates, and the improvement of the physiological properties of strain. Strains with enhanced titer, rate, and yield are now competing with traditional petroleum-based industrial approaches. This review highlights recent advances and perspectives in the metabolic engineering of yeasts for the production of a variety of compounds, including fuels, chemicals, proteins, and peptides, as well as advancements in synthetic biology tools and mathematical modeling. – Name: Format Label: File Description Group: SrcInfo Data: electronic – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://research.chalmers.se/publication/546527" linkWindow="_blank">https://research.chalmers.se/publication/546527</link><br /><link linkTarget="URL" linkTerm="https://research.chalmers.se/publication/546527/file/546527_Fulltext.pdf" linkWindow="_blank">https://research.chalmers.se/publication/546527/file/546527_Fulltext.pdf</link> |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1146/annurev-biophys-070924-103134 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 101 Subjects: – SubjectFull: yeast cell factory Type: general – SubjectFull: synthetic biology Type: general – SubjectFull: computational design Type: general – SubjectFull: Saccharomyces cerevisiae Type: general – SubjectFull: biorefinery Type: general – SubjectFull: metabolic engineering Type: general Titles: – TitleFull: Metabolic Engineering of Yeast Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shi, Shuobo – PersonEntity: Name: NameFull: Chen, Yu – PersonEntity: Name: NameFull: Nielsen, Jens B IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 1936122x – Type: issn-print Value: 19361238 – Type: issn-locals Value: SWEPUB_FREE – Type: issn-locals Value: CTH_SWEPUB Numbering: – Type: volume Value: 54 – Type: issue Value: 1 Titles: – TitleFull: Annual review of biophysics Type: main |
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