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Encapsulation-Induced Stress Helps Saccharomyces cerevisiae Resist Convertible Lignocellulose Derived Inhibitors

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Title: Encapsulation-Induced Stress Helps Saccharomyces cerevisiae Resist Convertible Lignocellulose Derived Inhibitors
Authors: Westman, Johan, 1983, Manikondu, R. B., Franzén, Carl Johan, 1966, Taherzadeh Esfahani, Mohammad, 1965
Source: International Journal of Molecular Sciences. 13(9):11881-11894
Subject Terms: anaerobic batch fermentation, furfural, acid, pretreatment, microencapsulation, lignocellulosic hydrolysate, conversion, ethanol, carboxylic acids, HMF (5-hydroxymethyl furfural), glucose, ethanol-production, yeast-cells, hydrolyzate, continuous cultivation
Description: The ability of macroencapsulated Saccharomyces cerevisiae CBS8066 to withstand readily and not readily in situ convertible lignocellulose-derived inhibitors was investigated in anaerobic batch cultivations. It was shown that encapsulation increased the tolerance against readily convertible furan aldehyde inhibitors and to dilute acid spruce hydrolysate, but not to organic acid inhibitors that cannot be metabolized anaerobically. Gene expression analysis showed that the protective effect arising from the encapsulation is evident also on the transcriptome level, as the expression of the stress-related genes YAP1, ATR1 and FLR1 was induced upon encapsulation. The transcript levels were increased due to encapsulation already in the medium without added inhibitors, indicating that the cells sensed low stress level arising from the encapsulation itself. We present a model, where the stress response is induced by nutrient limitation, that this helps the cells to cope with the increased stress added by a toxic medium, and that superficial cells in the capsules degrade convertible inhibitors, alleviating the inhibition for the cells deeper in the capsule.
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Encapsulation-Induced Stress Helps Saccharomyces cerevisiae Resist Convertible Lignocellulose Derived Inhibitors
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Westman%2C+Johan%22">Westman, Johan</searchLink>, 1983<br /><searchLink fieldCode="AR" term="%22Manikondu%2C+R%2E+B%2E%22">Manikondu, R. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Franzén%2C+Carl+Johan%22">Franzén, Carl Johan</searchLink>, 1966<br /><searchLink fieldCode="AR" term="%22Taherzadeh+Esfahani%2C+Mohammad%22">Taherzadeh Esfahani, Mohammad</searchLink>, 1965
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  Label: Source
  Group: Src
  Data: <i>International Journal of Molecular Sciences</i>. 13(9):11881-11894
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22anaerobic+batch+fermentation%22">anaerobic batch fermentation</searchLink><br /><searchLink fieldCode="DE" term="%22furfural%22">furfural</searchLink><br /><searchLink fieldCode="DE" term="%22acid%22">acid</searchLink><br /><searchLink fieldCode="DE" term="%22pretreatment%22">pretreatment</searchLink><br /><searchLink fieldCode="DE" term="%22microencapsulation%22">microencapsulation</searchLink><br /><searchLink fieldCode="DE" term="%22lignocellulosic+hydrolysate%22">lignocellulosic hydrolysate</searchLink><br /><searchLink fieldCode="DE" term="%22conversion%22">conversion</searchLink><br /><searchLink fieldCode="DE" term="%22ethanol%22">ethanol</searchLink><br /><searchLink fieldCode="DE" term="%22carboxylic+acids%22">carboxylic acids</searchLink><br /><searchLink fieldCode="DE" term="%22HMF+%285-hydroxymethyl+furfural%29%22">HMF (5-hydroxymethyl furfural)</searchLink><br /><searchLink fieldCode="DE" term="%22glucose%22">glucose</searchLink><br /><searchLink fieldCode="DE" term="%22ethanol-production%22">ethanol-production</searchLink><br /><searchLink fieldCode="DE" term="%22yeast-cells%22">yeast-cells</searchLink><br /><searchLink fieldCode="DE" term="%22hydrolyzate%22">hydrolyzate</searchLink><br /><searchLink fieldCode="DE" term="%22continuous+cultivation%22">continuous cultivation</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: The ability of macroencapsulated Saccharomyces cerevisiae CBS8066 to withstand readily and not readily in situ convertible lignocellulose-derived inhibitors was investigated in anaerobic batch cultivations. It was shown that encapsulation increased the tolerance against readily convertible furan aldehyde inhibitors and to dilute acid spruce hydrolysate, but not to organic acid inhibitors that cannot be metabolized anaerobically. Gene expression analysis showed that the protective effect arising from the encapsulation is evident also on the transcriptome level, as the expression of the stress-related genes YAP1, ATR1 and FLR1 was induced upon encapsulation. The transcript levels were increased due to encapsulation already in the medium without added inhibitors, indicating that the cells sensed low stress level arising from the encapsulation itself. We present a model, where the stress response is induced by nutrient limitation, that this helps the cells to cope with the increased stress added by a toxic medium, and that superficial cells in the capsules degrade convertible inhibitors, alleviating the inhibition for the cells deeper in the capsule.
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      – Type: doi
        Value: 10.3390/ijms130911881
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 11881
    Subjects:
      – SubjectFull: anaerobic batch fermentation
        Type: general
      – SubjectFull: furfural
        Type: general
      – SubjectFull: acid
        Type: general
      – SubjectFull: pretreatment
        Type: general
      – SubjectFull: microencapsulation
        Type: general
      – SubjectFull: lignocellulosic hydrolysate
        Type: general
      – SubjectFull: conversion
        Type: general
      – SubjectFull: ethanol
        Type: general
      – SubjectFull: carboxylic acids
        Type: general
      – SubjectFull: HMF (5-hydroxymethyl furfural)
        Type: general
      – SubjectFull: glucose
        Type: general
      – SubjectFull: ethanol-production
        Type: general
      – SubjectFull: yeast-cells
        Type: general
      – SubjectFull: hydrolyzate
        Type: general
      – SubjectFull: continuous cultivation
        Type: general
    Titles:
      – TitleFull: Encapsulation-Induced Stress Helps Saccharomyces cerevisiae Resist Convertible Lignocellulose Derived Inhibitors
        Type: main
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            NameFull: Westman, Johan
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            NameFull: Manikondu, R. B.
      – PersonEntity:
          Name:
            NameFull: Franzén, Carl Johan
      – PersonEntity:
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            NameFull: Taherzadeh Esfahani, Mohammad
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            – D: 01
              M: 01
              Type: published
              Y: 2012
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