View in EDS

Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography

Saved in:
Bibliographic Details
Title: Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography
Authors: Flehr, Alison, Källgård, Julius, Alvén, Jennifer, 1989, Lagerstrand, Kerstin M, Papalini, Evin, Wheeler, Michael, Vandenput, Liesbeth, Kahl, Fredrik, 1972, Axelsson, Kristian F., Sundh, Daniel, Mysore, Raghunath Shirish, Lorentzon, Mattias, 1970
Source: Osteoporosis International. 33(7):1545-1556
Subject Terms: Bone marrow adipose tissue (BMAT), High-resolution peripheral quantitative computed tomography (HR-pQCT, Bone mineral density (BMD), Magnetic resonance imaging (MRI)
Description: Bone marrow adipose tissue (BMAT) has been implicated in a number of conditions associated with bone deterioration and osteoporosis. Several studies have found an inverse relationship between BMAT and bone mineral density (BMD), and higher levels of BMAT in those with prevalent fracture. Magnetic resonance imaging (MRI) is the gold standard for measuring BMAT, but its use is limited by high costs and low availability. We hypothesized that BMAT could also be accurately quantified using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods: In the present study, a novel method to quantify the tibia bone marrow fat fraction, defined by MRI, using HR-pQCT was developed. In total, 38 postmenopausal women (mean [standard deviation] age 75.9 [3.1] years) were included and measured at the same site at the distal (n = 38) and ultradistal (n = 18) tibia using both MRI and HR-pQCT. To adjust for partial volume effects, the HR-pQCT images underwent 0 to 10 layers of voxel peeling to remove voxels adjacent to the bone. Linear regression equations were then tested for different degrees of voxel peeling, using the MRI-derived fat fractions as the dependent variable and the HR-pQCT-derived radiodensity as the independent variables. Results: The most optimal HR-pQCT derived model, which applied a minimum of 4 layers of peeled voxel and with more than 1% remaining marrow volume, was able to explain 76% of the variation in the ultradistal tibia bone marrow fat fraction, measured with MRI (p < 0.001). Conclusion: The novel HR-pQCT method, developed to estimate BMAT, was able to explain a substantial part of the variation in the bone marrow fat fraction and can be used in future studies investigating the role of BMAT in osteoporosis and fracture prediction.
File Description: electronic
Access URL: https://research.chalmers.se/publication/528659
https://research.chalmers.se/publication/528659/file/528659_Fulltext.pdf
Database: SwePub
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://research.chalmers.se/publication/528659#
    Name: EDS - SwePub (s4221598)
    Category: fullText
    Text: View record in SwePub
  – Url: https://resolver.ebscohost.com/openurl?sid=EBSCO:edsswe&genre=article&issn=0937941X&ISBN=&volume=33&issue=7&date=20220101&spage=1545&pages=1545-1556&title=Osteoporosis International&atitle=Development%20of%20a%20novel%20method%20to%20measure%20bone%20marrow%20fat%20fraction%20in%20older%20women%20using%20high-resolution%20peripheral%20quantitative%20computed%20tomography&aulast=Flehr%2C%20Alison&id=DOI:10.1007/s00198-021-06224-7
    Name: Full Text Finder
    Category: fullText
    Text: Full Text Finder
    Icon: https://imageserver.ebscohost.com/branding/images/FTF.gif
    MouseOverText: Full Text Finder
  – Url: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=EBSCO&SrcAuth=EBSCO&DestApp=WOS&ServiceName=TransferToWoS&DestLinkType=GeneralSearchSummary&Func=Links&author=Flehr%20A
    Name: ISI
    Category: fullText
    Text: Nájsť tento článok vo Web of Science
    Icon: https://imagesrvr.epnet.com/ls/20docs.gif
    MouseOverText: Nájsť tento článok vo Web of Science
Header DbId: edsswe
DbLabel: SwePub
An: edsswe.oai.research.chalmers.se.cefabac4.f38d.49b7.b3df.e2f0a1c9aef8
RelevancyScore: 1011
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1011.01770019531
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Flehr%2C+Alison%22&quot;&gt;Flehr, Alison&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22K&#228;llg&#229;rd%2C+Julius%22&quot;&gt;K&#228;llg&#229;rd, Julius&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alv&#233;n%2C+Jennifer%22&quot;&gt;Alv&#233;n, Jennifer&lt;/searchLink&gt;, 1989&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lagerstrand%2C+Kerstin+M%22&quot;&gt;Lagerstrand, Kerstin M&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Papalini%2C+Evin%22&quot;&gt;Papalini, Evin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wheeler%2C+Michael%22&quot;&gt;Wheeler, Michael&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vandenput%2C+Liesbeth%22&quot;&gt;Vandenput, Liesbeth&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kahl%2C+Fredrik%22&quot;&gt;Kahl, Fredrik&lt;/searchLink&gt;, 1972&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Axelsson%2C+Kristian+F%2E%22&quot;&gt;Axelsson, Kristian F.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sundh%2C+Daniel%22&quot;&gt;Sundh, Daniel&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mysore%2C+Raghunath+Shirish%22&quot;&gt;Mysore, Raghunath Shirish&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lorentzon%2C+Mattias%22&quot;&gt;Lorentzon, Mattias&lt;/searchLink&gt;, 1970
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;i&gt;Osteoporosis International&lt;/i&gt;. 33(7):1545-1556
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bone+marrow+adipose+tissue+%28BMAT%29%22&quot;&gt;Bone marrow adipose tissue (BMAT)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22High-resolution+peripheral+quantitative+computed+tomography+%28HR-pQCT%22&quot;&gt;High-resolution peripheral quantitative computed tomography (HR-pQCT&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bone+mineral+density+%28BMD%29%22&quot;&gt;Bone mineral density (BMD)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging+%28MRI%29%22&quot;&gt;Magnetic resonance imaging (MRI)&lt;/searchLink&gt;
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Bone marrow adipose tissue (BMAT) has been implicated in a number of conditions associated with bone deterioration and osteoporosis. Several studies have found an inverse relationship between BMAT and bone mineral density (BMD), and higher levels of BMAT in those with prevalent fracture. Magnetic resonance imaging (MRI) is the gold standard for measuring BMAT, but its use is limited by high costs and low availability. We hypothesized that BMAT could also be accurately quantified using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods: In the present study, a novel method to quantify the tibia bone marrow fat fraction, defined by MRI, using HR-pQCT was developed. In total, 38 postmenopausal women (mean [standard deviation] age 75.9 [3.1] years) were included and measured at the same site at the distal (n = 38) and ultradistal (n = 18) tibia using both MRI and HR-pQCT. To adjust for partial volume effects, the HR-pQCT images underwent 0 to 10 layers of voxel peeling to remove voxels adjacent to the bone. Linear regression equations were then tested for different degrees of voxel peeling, using the MRI-derived fat fractions as the dependent variable and the HR-pQCT-derived radiodensity as the independent variables. Results: The most optimal HR-pQCT derived model, which applied a minimum of 4 layers of peeled voxel and with more than 1% remaining marrow volume, was able to explain 76% of the variation in the ultradistal tibia bone marrow fat fraction, measured with MRI (p &lt; 0.001). Conclusion: The novel HR-pQCT method, developed to estimate BMAT, was able to explain a substantial part of the variation in the bone marrow fat fraction and can be used in future studies investigating the role of BMAT in osteoporosis and fracture prediction.
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic
– Name: URL
  Label: Access URL
  Group: URL
  Data: &lt;link linkTarget=&quot;URL&quot; linkTerm=&quot;https://research.chalmers.se/publication/528659&quot; linkWindow=&quot;_blank&quot;&gt;https://research.chalmers.se/publication/528659&lt;/link&gt;&lt;br /&gt;&lt;link linkTarget=&quot;URL&quot; linkTerm=&quot;https://research.chalmers.se/publication/528659/file/528659_Fulltext.pdf&quot; linkWindow=&quot;_blank&quot;&gt;https://research.chalmers.se/publication/528659/file/528659_Fulltext.pdf&lt;/link&gt;
PLink https://erproxy.cvtisr.sk/sfx/access?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsswe&AN=edsswe.oai.research.chalmers.se.cefabac4.f38d.49b7.b3df.e2f0a1c9aef8
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00198-021-06224-7
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1545
    Subjects:
      – SubjectFull: Bone marrow adipose tissue (BMAT)
        Type: general
      – SubjectFull: High-resolution peripheral quantitative computed tomography (HR-pQCT
        Type: general
      – SubjectFull: Bone mineral density (BMD)
        Type: general
      – SubjectFull: Magnetic resonance imaging (MRI)
        Type: general
    Titles:
      – TitleFull: Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Flehr, Alison
      – PersonEntity:
          Name:
            NameFull: Källgård, Julius
      – PersonEntity:
          Name:
            NameFull: Alvén, Jennifer
      – PersonEntity:
          Name:
            NameFull: Lagerstrand, Kerstin M
      – PersonEntity:
          Name:
            NameFull: Papalini, Evin
      – PersonEntity:
          Name:
            NameFull: Wheeler, Michael
      – PersonEntity:
          Name:
            NameFull: Vandenput, Liesbeth
      – PersonEntity:
          Name:
            NameFull: Kahl, Fredrik
      – PersonEntity:
          Name:
            NameFull: Axelsson, Kristian F.
      – PersonEntity:
          Name:
            NameFull: Sundh, Daniel
      – PersonEntity:
          Name:
            NameFull: Mysore, Raghunath Shirish
      – PersonEntity:
          Name:
            NameFull: Lorentzon, Mattias
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 0937941X
            – Type: issn-print
              Value: 14332965
            – Type: issn-locals
              Value: SWEPUB_FREE
            – Type: issn-locals
              Value: CTH_SWEPUB
          Numbering:
            – Type: volume
              Value: 33
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Osteoporosis International
              Type: main
ResultId 1