Metabolomic profiles of mid-trimester amniotic fluid are not associated with subsequent spontaneous preterm delivery or gestational duration at delivery
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| Titel: | Metabolomic profiles of mid-trimester amniotic fluid are not associated with subsequent spontaneous preterm delivery or gestational duration at delivery |
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| Autoren: | Hallingstrom, Maria, Barman, Malin, 1983, Savolainen, Otto, 1982, Viklund, Felicia, Kacerovsky, M., Brunius, Carl, 1974, Jacobsson, Bo |
| Quelle: | Journal of Maternal-Fetal and Neonatal Medicine. 35(11):2054-2062 |
| Schlagwörter: | spontaneous preterm delivery, mid-trimester, Amniotic fluid, gestational duration, metabolomics |
| Beschreibung: | Introduction:Spontaneous preterm delivery (<37 gestational weeks) has a multifactorial etiology with still incompletely identified pathways. Amniotic fluid is a biofluid with great potential for insights into the feto-maternal milieu. It is rich in metabolites, and metabolic consequences of inflammation is yet researched only to a limited extent. Metabolomic profiling provides opportunities to identify potential biomarkers of inflammatory conditioned pregnancy complications such as spontaneous preterm delivery. Objective:The aim of this study was to perform metabolomic profiling of amniotic fluid from uncomplicated singleton pregnancies in the mid-trimester to identify potential biomarkers associated with spontaneous preterm delivery and gestational duration at delivery. A secondary aim was to replicate previously reported mid-trimester amniotic fluid metabolic biomarkers of spontaneous preterm delivery in asymptomatic women. Method:A nested case-control study was performed within a larger cohort study of asymptomatic pregnant women undergoing mid-trimester genetic amniocentesis at 14-19 gestational weeks in Gothenburg, Sweden. Medical records were used to obtain clinical data and delivery outcome variables. Amniotic fluid samples from women with a subsequent spontaneous preterm delivery (n = 37) were matched with amniotic fluid samples from women with a subsequent spontaneous delivery at term (n = 37). Amniotic fluid samples underwent untargeted metabolomic analyses using liquid chromatography-mass spectrometry. Multivariate random forest analyses were used for data processing. A secondary targeted analysis was performed, aiming to replicate previously reported mid-trimester amniotic fluid metabolic biomarkers in women with a subsequent spontaneous preterm delivery. Results:Multivariate analysis did not distinguish the samples from women with a subsequent spontaneous preterm delivery from those with a subsequent term delivery. Neither was the metabolic profile associated with gestational duration at delivery. Potential metabolic biomarker candidates were identified from four publications by two different research groups relating mid-trimester amniotic fluid metabolomes to spontaneous PTD, of which fifteen markers were included in the secondary analysis. None of these were replicated. Conclusions:Metabolomic profiles of early mid-trimester amniotic fluid were not associated with spontaneous preterm delivery or gestational duration at delivery in this cohort. |
| Dateibeschreibung: | electronic |
| Zugangs-URL: | https://research.chalmers.se/publication/518016 https://research.chalmers.se/publication/518016/file/518016_Fulltext.pdf |
| Datenbank: | SwePub |
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| Items | – Name: Title Label: Title Group: Ti Data: Metabolomic profiles of mid-trimester amniotic fluid are not associated with subsequent spontaneous preterm delivery or gestational duration at delivery – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hallingstrom%2C+Maria%22">Hallingstrom, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Barman%2C+Malin%22">Barman, Malin</searchLink>, 1983<br /><searchLink fieldCode="AR" term="%22Savolainen%2C+Otto%22">Savolainen, Otto</searchLink>, 1982<br /><searchLink fieldCode="AR" term="%22Viklund%2C+Felicia%22">Viklund, Felicia</searchLink><br /><searchLink fieldCode="AR" term="%22Kacerovsky%2C+M%2E%22">Kacerovsky, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Brunius%2C+Carl%22">Brunius, Carl</searchLink>, 1974<br /><searchLink fieldCode="AR" term="%22Jacobsson%2C+Bo%22">Jacobsson, Bo</searchLink> – Name: TitleSource Label: Source Group: Src Data: <i>Journal of Maternal-Fetal and Neonatal Medicine</i>. 35(11):2054-2062 – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22spontaneous+preterm+delivery%22">spontaneous preterm delivery</searchLink><br /><searchLink fieldCode="DE" term="%22mid-trimester%22">mid-trimester</searchLink><br /><searchLink fieldCode="DE" term="%22Amniotic+fluid%22">Amniotic fluid</searchLink><br /><searchLink fieldCode="DE" term="%22gestational+duration%22">gestational duration</searchLink><br /><searchLink fieldCode="DE" term="%22metabolomics%22">metabolomics</searchLink> – Name: Abstract Label: Description Group: Ab Data: Introduction:Spontaneous preterm delivery (<37 gestational weeks) has a multifactorial etiology with still incompletely identified pathways. Amniotic fluid is a biofluid with great potential for insights into the feto-maternal milieu. It is rich in metabolites, and metabolic consequences of inflammation is yet researched only to a limited extent. Metabolomic profiling provides opportunities to identify potential biomarkers of inflammatory conditioned pregnancy complications such as spontaneous preterm delivery. Objective:The aim of this study was to perform metabolomic profiling of amniotic fluid from uncomplicated singleton pregnancies in the mid-trimester to identify potential biomarkers associated with spontaneous preterm delivery and gestational duration at delivery. A secondary aim was to replicate previously reported mid-trimester amniotic fluid metabolic biomarkers of spontaneous preterm delivery in asymptomatic women. Method:A nested case-control study was performed within a larger cohort study of asymptomatic pregnant women undergoing mid-trimester genetic amniocentesis at 14-19 gestational weeks in Gothenburg, Sweden. Medical records were used to obtain clinical data and delivery outcome variables. Amniotic fluid samples from women with a subsequent spontaneous preterm delivery (n = 37) were matched with amniotic fluid samples from women with a subsequent spontaneous delivery at term (n = 37). Amniotic fluid samples underwent untargeted metabolomic analyses using liquid chromatography-mass spectrometry. Multivariate random forest analyses were used for data processing. A secondary targeted analysis was performed, aiming to replicate previously reported mid-trimester amniotic fluid metabolic biomarkers in women with a subsequent spontaneous preterm delivery. Results:Multivariate analysis did not distinguish the samples from women with a subsequent spontaneous preterm delivery from those with a subsequent term delivery. Neither was the metabolic profile associated with gestational duration at delivery. Potential metabolic biomarker candidates were identified from four publications by two different research groups relating mid-trimester amniotic fluid metabolomes to spontaneous PTD, of which fifteen markers were included in the secondary analysis. None of these were replicated. Conclusions:Metabolomic profiles of early mid-trimester amniotic fluid were not associated with spontaneous preterm delivery or gestational duration at delivery in this cohort. – Name: Format Label: File Description Group: SrcInfo Data: electronic – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://research.chalmers.se/publication/518016" linkWindow="_blank">https://research.chalmers.se/publication/518016</link><br /><link linkTarget="URL" linkTerm="https://research.chalmers.se/publication/518016/file/518016_Fulltext.pdf" linkWindow="_blank">https://research.chalmers.se/publication/518016/file/518016_Fulltext.pdf</link> |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/14767058.2020.1777271 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 2054 Subjects: – SubjectFull: spontaneous preterm delivery Type: general – SubjectFull: mid-trimester Type: general – SubjectFull: Amniotic fluid Type: general – SubjectFull: gestational duration Type: general – SubjectFull: metabolomics Type: general Titles: – TitleFull: Metabolomic profiles of mid-trimester amniotic fluid are not associated with subsequent spontaneous preterm delivery or gestational duration at delivery Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hallingstrom, Maria – PersonEntity: Name: NameFull: Barman, Malin – PersonEntity: Name: NameFull: Savolainen, Otto – PersonEntity: Name: NameFull: Viklund, Felicia – PersonEntity: Name: NameFull: Kacerovsky, M. – PersonEntity: Name: NameFull: Brunius, Carl – PersonEntity: Name: NameFull: Jacobsson, Bo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 14767058 – Type: issn-print Value: 14764954 – Type: issn-locals Value: SWEPUB_FREE – Type: issn-locals Value: CTH_SWEPUB Numbering: – Type: volume Value: 35 – Type: issue Value: 11 Titles: – TitleFull: Journal of Maternal-Fetal and Neonatal Medicine Type: main |
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