Zobrazit v EDS

Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast

Uloženo v:
Podrobná bibliografie
Název: Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast
Autoři: Malina, Carl, 1992, Brown, Rosemary, 1990, Björkeroth, Johan, 1990, Kerkhoven, Eduard, 1985, Nielsen, Jens B, 1962
Zdroj: Proceedings of the National Academy of Sciences of the United States of America. 118(51)
Témata: Constraint-based modeling, Proteomics, Systems biology, Yeast, Crabtree effect
Popis: Aerobic fermentation, also referred to as the Crabtree effect in yeast, is a well-studied phenomenon that allows many eukaryal cells to attain higher growth rates at high glucose availability. Not all yeasts exhibit the Crabtree effect, and it is not known why Crabtree-negative yeasts can grow at rates comparable to Crabtree-positive yeasts. Here, we quantitatively compared two Crabtree-positive yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, and two Crabtree-negative yeasts, Kluyveromyces marxianus and Scheffersomyces stipitis, cultivated under glucose excess conditions. Combining physiological and proteome quantification with genome-scale metabolic modeling, we found that the two groups differ in energy metabolism and translation efficiency. In Crabtree-positive yeasts, the central carbon metabolism flux and proteome allocation favor a glucose utilization strategy minimizing proteome cost as proteins translation parameters, including ribosomal content and/or efficiency, are lower. Crabtree-negative yeasts, however, use a strategy of maximizing ATP yield, accompanied by higher protein translation parameters. Our analyses provide insight into the underlying reasons for the Crabtree effect, demonstrating a coupling to adaptations in both metabolism and protein translation.
Popis souboru: electronic
Přístupová URL adresa: https://research.chalmers.se/publication/528253
https://research.chalmers.se/publication/528253/file/528253_Fulltext.pdf
Databáze: SwePub
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://research.chalmers.se/publication/528253#
    Name: EDS - SwePub (s4221598)
    Category: fullText
    Text: View record in SwePub
  – Url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pmc&term=0027-8424[TA]+AND+[PG]+AND+2021[PDAT]
    Name: FREE - PubMed Central (ISSN based link)
    Category: fullText
    Text: Full Text
    Icon: https://imageserver.ebscohost.com/NetImages/iconPdf.gif
    MouseOverText: Check this PubMed for the article full text.
  – Url: https://resolver.ebscohost.com/openurl?sid=EBSCO:edsswe&genre=article&issn=00278424&ISBN=&volume=118&issue=51&date=20210101&spage=&pages=&title=Proceedings of the National Academy of Sciences of the United States of America&atitle=Adaptations%20in%20metabolism%20and%20protein%20translation%20give%20rise%20to%20the%20Crabtree%20effect%20in%20yeast&aulast=Malina%2C%20Carl&id=DOI:10.1073/pnas.2112836118
    Name: Full Text Finder
    Category: fullText
    Text: Full Text Finder
    Icon: https://imageserver.ebscohost.com/branding/images/FTF.gif
    MouseOverText: Full Text Finder
  – Url: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=EBSCO&SrcAuth=EBSCO&DestApp=WOS&ServiceName=TransferToWoS&DestLinkType=GeneralSearchSummary&Func=Links&author=Malina%20C
    Name: ISI
    Category: fullText
    Text: Nájsť tento článok vo Web of Science
    Icon: https://imagesrvr.epnet.com/ls/20docs.gif
    MouseOverText: Nájsť tento článok vo Web of Science
Header DbId: edsswe
DbLabel: SwePub
An: edsswe.oai.research.chalmers.se.79865ec8.1a7c.4dac.acf4.c5c073536fd8
RelevancyScore: 954
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 954.003845214844
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Malina%2C+Carl%22">Malina, Carl</searchLink>, 1992<br /><searchLink fieldCode="AR" term="%22Brown%2C+Rosemary%22">Brown, Rosemary</searchLink>, 1990<br /><searchLink fieldCode="AR" term="%22Björkeroth%2C+Johan%22">Björkeroth, Johan</searchLink>, 1990<br /><searchLink fieldCode="AR" term="%22Kerkhoven%2C+Eduard%22">Kerkhoven, Eduard</searchLink>, 1985<br /><searchLink fieldCode="AR" term="%22Nielsen%2C+Jens+B%22">Nielsen, Jens B</searchLink>, 1962
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 118(51)
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Constraint-based+modeling%22">Constraint-based modeling</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink><br /><searchLink fieldCode="DE" term="%22Systems+biology%22">Systems biology</searchLink><br /><searchLink fieldCode="DE" term="%22Yeast%22">Yeast</searchLink><br /><searchLink fieldCode="DE" term="%22Crabtree+effect%22">Crabtree effect</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Aerobic fermentation, also referred to as the Crabtree effect in yeast, is a well-studied phenomenon that allows many eukaryal cells to attain higher growth rates at high glucose availability. Not all yeasts exhibit the Crabtree effect, and it is not known why Crabtree-negative yeasts can grow at rates comparable to Crabtree-positive yeasts. Here, we quantitatively compared two Crabtree-positive yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, and two Crabtree-negative yeasts, Kluyveromyces marxianus and Scheffersomyces stipitis, cultivated under glucose excess conditions. Combining physiological and proteome quantification with genome-scale metabolic modeling, we found that the two groups differ in energy metabolism and translation efficiency. In Crabtree-positive yeasts, the central carbon metabolism flux and proteome allocation favor a glucose utilization strategy minimizing proteome cost as proteins translation parameters, including ribosomal content and/or efficiency, are lower. Crabtree-negative yeasts, however, use a strategy of maximizing ATP yield, accompanied by higher protein translation parameters. Our analyses provide insight into the underlying reasons for the Crabtree effect, demonstrating a coupling to adaptations in both metabolism and protein translation.
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://research.chalmers.se/publication/528253" linkWindow="_blank">https://research.chalmers.se/publication/528253</link><br /><link linkTarget="URL" linkTerm="https://research.chalmers.se/publication/528253/file/528253_Fulltext.pdf" linkWindow="_blank">https://research.chalmers.se/publication/528253/file/528253_Fulltext.pdf</link>
PLink https://erproxy.cvtisr.sk/sfx/access?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsswe&AN=edsswe.oai.research.chalmers.se.79865ec8.1a7c.4dac.acf4.c5c073536fd8
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1073/pnas.2112836118
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Constraint-based modeling
        Type: general
      – SubjectFull: Proteomics
        Type: general
      – SubjectFull: Systems biology
        Type: general
      – SubjectFull: Yeast
        Type: general
      – SubjectFull: Crabtree effect
        Type: general
    Titles:
      – TitleFull: Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Malina, Carl
      – PersonEntity:
          Name:
            NameFull: Brown, Rosemary
      – PersonEntity:
          Name:
            NameFull: Björkeroth, Johan
      – PersonEntity:
          Name:
            NameFull: Kerkhoven, Eduard
      – PersonEntity:
          Name:
            NameFull: Nielsen, Jens B
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 00278424
            – Type: issn-print
              Value: 10916490
            – Type: issn-locals
              Value: SWEPUB_FREE
            – Type: issn-locals
              Value: CTH_SWEPUB
          Numbering:
            – Type: volume
              Value: 118
            – Type: issue
              Value: 51
          Titles:
            – TitleFull: Proceedings of the National Academy of Sciences of the United States of America
              Type: main
ResultId 1