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Postoperative word-finding difficulties in children with posterior fossa tumours: a crosslinguistic European cohort study

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Titel: Postoperative word-finding difficulties in children with posterior fossa tumours: a crosslinguistic European cohort study
Autoren: Persson, K, Grønbæk, J, Tiberg, I, Fyrberg, Å, Castor, C, Andreozzi, B, Frič, R, Hauser, P, Kiudeliene, R, Mallucci, C, Mathiasen, R, Nyman, P, Pizer, B, Sehested, A, Boeg Thomsen, D, CMS study group
Weitere Verfasser: Lund University, Faculty of Medicine, Department of Health Sciences, Proactive Integrated Care, Lunds universitet, Medicinska fakulteten, Institutionen för hälsovetenskaper, Proaktiv, integrerad vård, Originator, Lund University, Faculty of Medicine, Department of Health Sciences, Rehabilitation and Sustainable Health, Lunds universitet, Medicinska fakulteten, Institutionen för hälsovetenskaper, Rehabilitering och hållbar hälsa, Originator, Lund University, Profile areas and other strong research environments, Other Strong Research Environments, LUCC: Lund University Cancer Centre, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Övriga starka forskningsmiljöer, LUCC: Lunds universitets cancercentrum, Originator
Quelle: Child's Nervous System. 41:1-14
Schlagwörter: Medical and Health Sciences, Clinical Medicine, Surgery, Medicin och hälsovetenskap, Klinisk medicin, Kirurgi, Pediatrics, Pediatrik
Beschreibung: PURPOSE: Posterior fossa tumour (PFT) surgery carries a risk of mutism or severely reduced speech. As for higher-cognitive language functions, word-finding difficulties have been reported, but no study has compared pre- and postoperative word-finding speeds to identify impairment caused by surgery. The current study investigated changes in word-finding ability associated with PFT surgery and examined factors affecting postoperative ability. METHOD: We included 184 children aged 5:0-17:9 years undergoing PFT surgery and assessed word-finding ability before and after surgery using a speeded picture-naming test. We compared postoperative word-finding performance with both preoperative performance and age-specific norms and examined factors affecting word-finding ability. RESULTS: We found no significant difference between pre- and postoperative performance, reflecting that some children exhibited better word-finding ability after surgery, others poorer. After surgery, 95% of the children performed two standarddeviations above (slower than) age-specific norms. Tumour location in the fourth ventricle negatively affected postoperative word-finding ability (B = -4.09, p < 0.05). CONCLUSION: For some children, PFT surgery leads to postoperative word-finding difficulties, emphasizing the importance of postoperative language assessments and interventions. Fourth-ventricle tumour location emerged as a risk factor for poorer postoperative word-finding ability, likely reflecting surgical damage to the dentato-thalamo-cortical pathway (DTCP).
Zugangs-URL: https://doi.org/10.1007/s00381-025-06787-4
Datenbank: SwePub
Beschreibung
Abstract:PURPOSE: Posterior fossa tumour (PFT) surgery carries a risk of mutism or severely reduced speech. As for higher-cognitive language functions, word-finding difficulties have been reported, but no study has compared pre- and postoperative word-finding speeds to identify impairment caused by surgery. The current study investigated changes in word-finding ability associated with PFT surgery and examined factors affecting postoperative ability. METHOD: We included 184 children aged 5:0-17:9 years undergoing PFT surgery and assessed word-finding ability before and after surgery using a speeded picture-naming test. We compared postoperative word-finding performance with both preoperative performance and age-specific norms and examined factors affecting word-finding ability. RESULTS: We found no significant difference between pre- and postoperative performance, reflecting that some children exhibited better word-finding ability after surgery, others poorer. After surgery, 95% of the children performed two standarddeviations above (slower than) age-specific norms. Tumour location in the fourth ventricle negatively affected postoperative word-finding ability (B = -4.09, p < 0.05). CONCLUSION: For some children, PFT surgery leads to postoperative word-finding difficulties, emphasizing the importance of postoperative language assessments and interventions. Fourth-ventricle tumour location emerged as a risk factor for poorer postoperative word-finding ability, likely reflecting surgical damage to the dentato-thalamo-cortical pathway (DTCP).
ISSN:14330350
DOI:10.1007/s00381-025-06787-4