Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients
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| Title: | Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients |
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| Authors: | Ohlsson, Marcus Andreas, Nilsson, Christopher, Molvin, John, Isholth, Hannes Holm, Grubb, Anders, Christensson, Anders, Jujic, Amra, Magnusson, Martin |
| Contributors: | Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Cardiovascular Research - Hypertension, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Kardiovaskulär forskning - hypertoni, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Internal Medicine - Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Internmedicin - epidemiologi, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Cystatin C, renal disease, amyloidosis and antibiotics, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi och farmakologi, Cystatin C, njursjukdom, amyloidos och antibiotika, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EXODIAB: Excellence of Diabetes Research in Sweden, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EXODIAB: Excellence of Diabetes Research in Sweden, Originator, Lund University, Faculty of Medicine, WCMM-Wallenberg Centre for Molecular Medicine, Lunds universitet, Medicinska fakulteten, WCMM- Wallenberg center för molekylär medicinsk forskning, Originator |
| Source: | BMC Nephrology. 26:1-10 |
| Subject Terms: | Medical and Health Sciences, Clinical Medicine, Cardiology and Cardiovascular Disease, Medicin och hälsovetenskap, Klinisk medicin, Kardiologi och kardiovaskulära sjukdomar, Nephrology, Njurmedicin |
| Description: | BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease. PURPOSE: To explore if increased levels of OPN and SGHS are associated with hospitalization for kidney failure in patients with acute heart failure (HF). METHODS: OPN was analyzed in 315 hospitalized HF patients using a proximity extension assay. SGHS was defined as cystatin C-based estimated GFR (eGFR) < 60% of the creatinine-based eGFR. Clinical outcomes were retrieved from regional registries (ICD-10 N17-N19). Multivariable logistic and Cox regression models adjusted for known risk factors were used for associations between OPN and SGHS and their association with hospitalization for kidney failure. RESULTS: The mean age was 74 years, 33% were female and 15% presented with SGHS. Patients with SGHS had higher BMI, OPN- and cystatin C levels and higher mean eGFR. During the median follow-up period of 28 months, 46 patients were hospitalized for kidney failure. Increased OPN-levels were associated with prevalent SGHS (odds ratio 2.50, p < 0.001), and higher risk of hospitalization for acute kidney failure (hazard ratio (HR) 4.66, p < 0.001) as did prevalent SGHS (HR 4.82, p < 0.001). CONCLUSIONS: In HF patients, OPN was associated with a higher prevalence of SGHS and both OPN and SGHS were associated with higher risk of hospitalization for kidney failure. Our results suggest that OPN and SGHS can identify HF patients at high risk of kidney function decline. |
| Access URL: | https://doi.org/10.1186/s12882-025-04481-w |
| Database: | SwePub |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ohlsson%2C+Marcus+Andreas%22">Ohlsson, Marcus Andreas</searchLink><br /><searchLink fieldCode="AR" term="%22Nilsson%2C+Christopher%22">Nilsson, Christopher</searchLink><br /><searchLink fieldCode="AR" term="%22Molvin%2C+John%22">Molvin, John</searchLink><br /><searchLink fieldCode="AR" term="%22Isholth%2C+Hannes+Holm%22">Isholth, Hannes Holm</searchLink><br /><searchLink fieldCode="AR" term="%22Grubb%2C+Anders%22">Grubb, Anders</searchLink><br /><searchLink fieldCode="AR" term="%22Christensson%2C+Anders%22">Christensson, Anders</searchLink><br /><searchLink fieldCode="AR" term="%22Jujic%2C+Amra%22">Jujic, Amra</searchLink><br /><searchLink fieldCode="AR" term="%22Magnusson%2C+Martin%22">Magnusson, Martin</searchLink> – Name: Author Label: Contributors Group: Au Data: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Cardiovascular Research - Hypertension, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Kardiovaskulär forskning - hypertoni, Originator<br />Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Internal Medicine - Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Internmedicin - epidemiologi, Originator<br />Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Cystatin C, renal disease, amyloidosis and antibiotics, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi och farmakologi, Cystatin C, njursjukdom, amyloidos och antibiotika, Originator<br />Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator<br />Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EXODIAB: Excellence of Diabetes Research in Sweden, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EXODIAB: Excellence of Diabetes Research in Sweden, Originator<br />Lund University, Faculty of Medicine, WCMM-Wallenberg Centre for Molecular Medicine, Lunds universitet, Medicinska fakulteten, WCMM- Wallenberg center för molekylär medicinsk forskning, Originator – Name: TitleSource Label: Source Group: Src Data: <i>BMC Nephrology</i>. 26:1-10 – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Medical+and+Health+Sciences%22">Medical and Health Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+Medicine%22">Clinical Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiology+and+Cardiovascular+Disease%22">Cardiology and Cardiovascular Disease</searchLink><br /><searchLink fieldCode="DE" term="%22Medicin+och+hälsovetenskap%22">Medicin och hälsovetenskap</searchLink><br /><searchLink fieldCode="DE" term="%22Klinisk+medicin%22">Klinisk medicin</searchLink><br /><searchLink fieldCode="DE" term="%22Kardiologi+och+kardiovaskulära+sjukdomar%22">Kardiologi och kardiovaskulära sjukdomar</searchLink><br /><searchLink fieldCode="DE" term="%22Nephrology%22">Nephrology</searchLink><br /><searchLink fieldCode="DE" term="%22Njurmedicin%22">Njurmedicin</searchLink> – Name: Abstract Label: Description Group: Ab Data: BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease. PURPOSE: To explore if increased levels of OPN and SGHS are associated with hospitalization for kidney failure in patients with acute heart failure (HF). METHODS: OPN was analyzed in 315 hospitalized HF patients using a proximity extension assay. SGHS was defined as cystatin C-based estimated GFR (eGFR) < 60% of the creatinine-based eGFR. Clinical outcomes were retrieved from regional registries (ICD-10 N17-N19). Multivariable logistic and Cox regression models adjusted for known risk factors were used for associations between OPN and SGHS and their association with hospitalization for kidney failure. RESULTS: The mean age was 74 years, 33% were female and 15% presented with SGHS. Patients with SGHS had higher BMI, OPN- and cystatin C levels and higher mean eGFR. During the median follow-up period of 28 months, 46 patients were hospitalized for kidney failure. Increased OPN-levels were associated with prevalent SGHS (odds ratio 2.50, p < 0.001), and higher risk of hospitalization for acute kidney failure (hazard ratio (HR) 4.66, p < 0.001) as did prevalent SGHS (HR 4.82, p < 0.001). CONCLUSIONS: In HF patients, OPN was associated with a higher prevalence of SGHS and both OPN and SGHS were associated with higher risk of hospitalization for kidney failure. Our results suggest that OPN and SGHS can identify HF patients at high risk of kidney function decline. – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://doi.org/10.1186/s12882-025-04481-w" linkWindow="_blank">https://doi.org/10.1186/s12882-025-04481-w</link> |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12882-025-04481-w Languages: – Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: Medical and Health Sciences Type: general – SubjectFull: Clinical Medicine Type: general – SubjectFull: Cardiology and Cardiovascular Disease Type: general – SubjectFull: Medicin och hälsovetenskap Type: general – SubjectFull: Klinisk medicin Type: general – SubjectFull: Kardiologi och kardiovaskulära sjukdomar Type: general – SubjectFull: Nephrology Type: general – SubjectFull: Njurmedicin Type: general Titles: – TitleFull: Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ohlsson, Marcus Andreas – PersonEntity: Name: NameFull: Nilsson, Christopher – PersonEntity: Name: NameFull: Molvin, John – PersonEntity: Name: NameFull: Isholth, Hannes Holm – PersonEntity: Name: NameFull: Grubb, Anders – PersonEntity: Name: NameFull: Christensson, Anders – PersonEntity: Name: NameFull: Jujic, Amra – PersonEntity: Name: NameFull: Magnusson, Martin – PersonEntity: Name: NameFull: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Cardiovascular Research - Hypertension, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Kardiovaskulär forskning - hypertoni, Originator – PersonEntity: Name: NameFull: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Internal Medicine - Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Internmedicin - epidemiologi, Originator – PersonEntity: Name: NameFull: Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Cystatin C, renal disease, amyloidosis and antibiotics, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi och farmakologi, Cystatin C, njursjukdom, amyloidos och antibiotika, Originator – PersonEntity: Name: NameFull: Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator – PersonEntity: Name: NameFull: Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EXODIAB: Excellence of Diabetes Research in Sweden, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EXODIAB: Excellence of Diabetes Research in Sweden, Originator – PersonEntity: Name: NameFull: Lund University, Faculty of Medicine, WCMM-Wallenberg Centre for Molecular Medicine, Lunds universitet, Medicinska fakulteten, WCMM- Wallenberg center för molekylär medicinsk forskning, Originator IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 10 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 14712369 – Type: issn-locals Value: SWEPUB_FREE – Type: issn-locals Value: LU_SWEPUB Numbering: – Type: volume Value: 26 Titles: – TitleFull: BMC Nephrology Type: main |
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