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Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients

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Titel: Association of Osteopontin and selective glomerular hypofiltration syndrome with hospitalization for kidney failure in acute heart failure patients
Autoren: Ohlsson, Marcus Andreas, Nilsson, Christopher, Molvin, John, Isholth, Hannes Holm, Grubb, Anders, Christensson, Anders, Jujic, Amra, Magnusson, Martin
Weitere Verfasser: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Cardiovascular Research - Hypertension, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Kardiovaskulär forskning - hypertoni, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Internal Medicine - Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Internmedicin - epidemiologi, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Cystatin C, renal disease, amyloidosis and antibiotics, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi och farmakologi, Cystatin C, njursjukdom, amyloidos och antibiotika, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EXODIAB: Excellence of Diabetes Research in Sweden, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EXODIAB: Excellence of Diabetes Research in Sweden, Originator, Lund University, Faculty of Medicine, WCMM-Wallenberg Centre for Molecular Medicine, Lunds universitet, Medicinska fakulteten, WCMM- Wallenberg center för molekylär medicinsk forskning, Originator
Quelle: BMC Nephrology. 26:1-10
Schlagwörter: Medical and Health Sciences, Clinical Medicine, Cardiology and Cardiovascular Disease, Medicin och hälsovetenskap, Klinisk medicin, Kardiologi och kardiovaskulära sjukdomar, Nephrology, Njurmedicin
Beschreibung: BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease. PURPOSE: To explore if increased levels of OPN and SGHS are associated with hospitalization for kidney failure in patients with acute heart failure (HF). METHODS: OPN was analyzed in 315 hospitalized HF patients using a proximity extension assay. SGHS was defined as cystatin C-based estimated GFR (eGFR) < 60% of the creatinine-based eGFR. Clinical outcomes were retrieved from regional registries (ICD-10 N17-N19). Multivariable logistic and Cox regression models adjusted for known risk factors were used for associations between OPN and SGHS and their association with hospitalization for kidney failure. RESULTS: The mean age was 74 years, 33% were female and 15% presented with SGHS. Patients with SGHS had higher BMI, OPN- and cystatin C levels and higher mean eGFR. During the median follow-up period of 28 months, 46 patients were hospitalized for kidney failure. Increased OPN-levels were associated with prevalent SGHS (odds ratio 2.50, p < 0.001), and higher risk of hospitalization for acute kidney failure (hazard ratio (HR) 4.66, p < 0.001) as did prevalent SGHS (HR 4.82, p < 0.001). CONCLUSIONS: In HF patients, OPN was associated with a higher prevalence of SGHS and both OPN and SGHS were associated with higher risk of hospitalization for kidney failure. Our results suggest that OPN and SGHS can identify HF patients at high risk of kidney function decline.
Zugangs-URL: https://doi.org/10.1186/s12882-025-04481-w
Datenbank: SwePub
Beschreibung
Abstract:BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease. PURPOSE: To explore if increased levels of OPN and SGHS are associated with hospitalization for kidney failure in patients with acute heart failure (HF). METHODS: OPN was analyzed in 315 hospitalized HF patients using a proximity extension assay. SGHS was defined as cystatin C-based estimated GFR (eGFR) < 60% of the creatinine-based eGFR. Clinical outcomes were retrieved from regional registries (ICD-10 N17-N19). Multivariable logistic and Cox regression models adjusted for known risk factors were used for associations between OPN and SGHS and their association with hospitalization for kidney failure. RESULTS: The mean age was 74 years, 33% were female and 15% presented with SGHS. Patients with SGHS had higher BMI, OPN- and cystatin C levels and higher mean eGFR. During the median follow-up period of 28 months, 46 patients were hospitalized for kidney failure. Increased OPN-levels were associated with prevalent SGHS (odds ratio 2.50, p < 0.001), and higher risk of hospitalization for acute kidney failure (hazard ratio (HR) 4.66, p < 0.001) as did prevalent SGHS (HR 4.82, p < 0.001). CONCLUSIONS: In HF patients, OPN was associated with a higher prevalence of SGHS and both OPN and SGHS were associated with higher risk of hospitalization for kidney failure. Our results suggest that OPN and SGHS can identify HF patients at high risk of kidney function decline.
ISSN:14712369
DOI:10.1186/s12882-025-04481-w