The ESCAPER Study - exploring protective mechanisms against cardiovascular disease in subjects at high risk: Rationale, study protocol, and first results
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| Název: | The ESCAPER Study - exploring protective mechanisms against cardiovascular disease in subjects at high risk: Rationale, study protocol, and first results |
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| Autoři: | Ekström, Ola, Arheden, Håkan, Christensson, Anders, Engström, Gunnar, Hedström, Erik, Kennbäck, Cecilia, Laucyte-Cibulskiene, Agne, Lundgren, Simon, Lyssenko, Valeriya, Löndahl, Magnus, Magnusson, Martin, Nilsson, Peter M, Gottsäter, Anders |
| Přispěvatelé: | Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EXODIAB: Excellence of Diabetes Research in Sweden, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EXODIAB: Excellence of Diabetes Research in Sweden, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Translational Muscle Research, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Translationell muskelforskning, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Clinical Physiology (Lund), Lund Cardiac MR Group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Klinisk fysiologi, Lund, Hjärt-MR-gruppen i Lund, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Internal Medicine - Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Internmedicin - epidemiologi, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Cardiovascular Research - Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Kardiovaskulär forskning - epidemiologi, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Pediatrisk radiologi, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Pediatrisk radiologi, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section II, Medicine/Emergency Medicine, Lund, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion II, Medicin/akutsjukvård, Lund, Originator, Lund University, Faculty of Medicine, WCMM-Wallenberg Centre for Molecular Medicine, Lunds universitet, Medicinska fakulteten, WCMM- Wallenberg center för molekylär medicinsk forskning, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Cardiovascular Research - Hypertension, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Kardiovaskulär forskning - hypertoni, Originator |
| Zdroj: | Scandinavian cardiovascular journal : SCJ. 59(1):1-7 |
| Témata: | Medical and Health Sciences, Clinical Medicine, Cardiology and Cardiovascular Disease, Medicin och hälsovetenskap, Klinisk medicin, Kardiologi och kardiovaskulära sjukdomar |
| Popis: | IntroductionThe ESCAPER project explores cardiovascular resilience in individuals who, despite a high-risk factor burden-longstanding Type 1 Diabetes (T1D), obesity, or kidney failure-avoid or delay macrovascular complications. This suggests underlying protective mechanisms. Initiated in September 2022, this exploratory study aims to uncover and define these mechanisms, potentially leading to novel therapeutic targets in preventive medicine.Research Design and MethodsParticipants from the Skåne region, Southern Sweden, are divided into three subgroups: (1) T1D patients (>30 years duration) without macrovascular complications or macroalbuminuria, (2) obese individuals with normal cardiac function and no cardiovascular medications, and (3) kidney failure patients awaiting transplantation with no arterial calcification, alongside respective controls. Comprehensive phenotyping includes 24-hour blood pressure, ECG monitoring, vascular ultrasound, cardiac MRI, and ergospirometry (in a subgroup), along with laboratory investigations, including biomarker and omics analyses. Arterial biopsies are collected from kidney failure patients. The study leverages Swedish national medical registries for detailed follow-up of healthcare utilization, diagnoses, and prescriptions, enabling longitudinal outcome assessments.ResultsInitial findings from 90 T1D patients and 31 obese individuals indicate well-managed cardiovascular risk factors. The T1D subgroup shows a mean BMI of 25.6 kg/m 2 and HbA1c of 52 mmol/mol, while the obesity subgroup presents a BMI of 32.9 kg/m 2 with normal glucose levels.ConclusionsESCAPER has the potential to advance understanding of cardiovascular resilience and refine prevention strategies. Its comprehensive methodology and registry-based follow-up provide robust insights into protective mechanisms and long-term outcomes. |
| Přístupová URL adresa: | https://doi.org/10.1080/14017431.2025.2513865 |
| Databáze: | SwePub |
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