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The Impact of the Parental Patterns of Morbidity and Comorbidity in the Cross-Generational Transmission of Risk for Major Depression and Alcohol Use Disorder

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Názov: The Impact of the Parental Patterns of Morbidity and Comorbidity in the Cross-Generational Transmission of Risk for Major Depression and Alcohol Use Disorder
Autori: Kendler, Kenneth S, Abrahamsson, Linda, Sundquist, Jan, Sundquist, Kristina
Prispievatelia: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Family Medicine and Clinical Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Allmänmedicin och klinisk epidemiologi, Originator, Lund University, Profile areas and other strong research environments, Other Strong Research Environments, LUCC: Lund University Cancer Centre, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Övriga starka forskningsmiljöer, LUCC: Lunds universitets cancercentrum, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator
Zdroj: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.
Predmety: Medical and Health Sciences, Clinical Medicine, Psychiatry, Medicin och hälsovetenskap, Klinisk medicin, Psykiatri, Health Sciences, Drug Abuse and Addiction, Hälsovetenskap, Beroendelära och missbruk
Popis: To further understand the inter-relationship of the familial transmission of major depression (MD) and alcohol use disorder (AUD), we examine, via a multivariable Cox proportional hazards model, risks for AUD and MD in 1,244,516 individuals born in Sweden from 1970 to 1990 to intact mother-father pairs as a function of parental diagnoses of MD and/or AUD. Across the nine possible mating types, we see both direct transmission (MD → MD, AUD → AUD) and also, less strongly, indirect transmission: MD → AUD and AUD → MD. Risks in offspring accumulate with multiple affected parents, which reveals the impact of interactive effects in risk prediction. Interestingly, the risk for comorbid AUD/MD in offspring is higher when one parent has MD and the other AUD rather than when one parent has both disorders. Modest sex effects are seen, with maternal-offspring transmission sometimes significantly stronger than paternal-offspring transmission. In most comparisons, parental-offspring transmission was modestly stronger for same-sex versus opposite-sex parent-offspring pairs. These results suggest that MD/AUD comorbidity in Sweden is due, at least in part, to correlated familial liability transmitted by direct and indirect paths across generations. We could reject the hypothesis that an AUD/MD syndrome was specifically transmitted from parents to offspring.
Prístupová URL adresa: https://doi.org/10.1002/ajmg.b.33052
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  Data: The Impact of the Parental Patterns of Morbidity and Comorbidity in the Cross-Generational Transmission of Risk for Major Depression and Alcohol Use Disorder
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  Data: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Family Medicine and Clinical Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Allmänmedicin och klinisk epidemiologi, Originator<br />Lund University, Profile areas and other strong research environments, Other Strong Research Environments, LUCC: Lund University Cancer Centre, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Övriga starka forskningsmiljöer, LUCC: Lunds universitets cancercentrum, Originator<br />Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator
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  Data: To further understand the inter-relationship of the familial transmission of major depression (MD) and alcohol use disorder (AUD), we examine, via a multivariable Cox proportional hazards model, risks for AUD and MD in 1,244,516 individuals born in Sweden from 1970 to 1990 to intact mother-father pairs as a function of parental diagnoses of MD and/or AUD. Across the nine possible mating types, we see both direct transmission (MD → MD, AUD → AUD) and also, less strongly, indirect transmission: MD → AUD and AUD → MD. Risks in offspring accumulate with multiple affected parents, which reveals the impact of interactive effects in risk prediction. Interestingly, the risk for comorbid AUD/MD in offspring is higher when one parent has MD and the other AUD rather than when one parent has both disorders. Modest sex effects are seen, with maternal-offspring transmission sometimes significantly stronger than paternal-offspring transmission. In most comparisons, parental-offspring transmission was modestly stronger for same-sex versus opposite-sex parent-offspring pairs. These results suggest that MD/AUD comorbidity in Sweden is due, at least in part, to correlated familial liability transmitted by direct and indirect paths across generations. We could reject the hypothesis that an AUD/MD syndrome was specifically transmitted from parents to offspring.
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