Prostate cancer diagnostics: evolution over 30 years and the impact of education level – a prospective population-based study

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Title: Prostate cancer diagnostics: evolution over 30 years and the impact of education level – a prospective population-based study
Authors: Will, Leon, Thimansson, Erik, Bengtsson, Johan, Bjartell, Anders, Zackrisson, Sophia, Baubeta, Erik
Contributors: Lund University, Faculty of Medicine, Department of Translational Medicine, Radiology Diagnostics, Malmö, Lunds universitet, Medicinska fakulteten, Institutionen för translationell medicin, Diagnostisk radiologi, Malmö, Originator, Lund University, Profile areas and other strong research environments, Other Strong Research Environments, LUCC: Lund University Cancer Centre, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Övriga starka forskningsmiljöer, LUCC: Lunds universitets cancercentrum, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), eSSENCE: The e-Science Collaboration, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), eSSENCE: The e-Science Collaboration, Originator, Lund University, Faculty of Medicine, Department of Translational Medicine, Urological cancer, Malmö, Lunds universitet, Medicinska fakulteten, Institutionen för translationell medicin, Urologisk cancerforskning, Malmö, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator, Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Light and Materials, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Ljus och material, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Photon Science and Technology, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Avancerade ljuskällor, Originator
Source: Frontiers in Oncology. 15:01-10
Subject Terms: Medical and Health Sciences, Clinical Medicine, Urology, Medicin och hälsovetenskap, Klinisk medicin, Urologi, Cancer and Oncology, Cancer och onkologi, Basic Medicine, Epidemiology, Medicinska och farmaceutiska grundvetenskaper, Epidemiologi
Description: Objective: The aim of this study is to describe how the use of diagnostic imaging for prostate cancer (PCa) has evolved over time and to determine whether there are any differences in access to diagnostic imaging, type of cancers detected, and mortality based on the education level of patients. Methods: 11,063 men were recruited between 1991 and 1996 and then prospectively followed until 2020. All new cases of PCa were recorded. At baseline, data on education level, heredity for cancer, and health status were collected. Incident PCa diagnoses during the study period were ascertained through record matching with national healthcare registers. The registers provided more detailed data on the cancer type and imaging performed. Results: 1,816 men with diagnosed were PCa during the study period were included. No differences were seen between education levels in regard to access to diagnostic methods or tumour aggressiveness at diagnosis. Furthermore, no differences were seen in PCa-specific mortality,but there was higher overall mortality among individuals with a lower education level. During the study period, the use of plain radiographic examinations decreased, while the use of computed tomography (CT), prostate magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) increased. Conclusion: Early detection and diagnostic methods for PCa have evolved over the last 30 years. In a healthcare system where men diagnosed with PCa had equal access to diagnostic pathways, no differences are seen in PCa specific mortality. Nevertheless, men with lower education level still had higher overall mortality.
Access URL: https://doi.org/10.3389/fonc.2025.1636292
Database: SwePub
Description
Abstract:Objective: The aim of this study is to describe how the use of diagnostic imaging for prostate cancer (PCa) has evolved over time and to determine whether there are any differences in access to diagnostic imaging, type of cancers detected, and mortality based on the education level of patients. Methods: 11,063 men were recruited between 1991 and 1996 and then prospectively followed until 2020. All new cases of PCa were recorded. At baseline, data on education level, heredity for cancer, and health status were collected. Incident PCa diagnoses during the study period were ascertained through record matching with national healthcare registers. The registers provided more detailed data on the cancer type and imaging performed. Results: 1,816 men with diagnosed were PCa during the study period were included. No differences were seen between education levels in regard to access to diagnostic methods or tumour aggressiveness at diagnosis. Furthermore, no differences were seen in PCa-specific mortality,but there was higher overall mortality among individuals with a lower education level. During the study period, the use of plain radiographic examinations decreased, while the use of computed tomography (CT), prostate magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) increased. Conclusion: Early detection and diagnostic methods for PCa have evolved over the last 30 years. In a healthcare system where men diagnosed with PCa had equal access to diagnostic pathways, no differences are seen in PCa specific mortality. Nevertheless, men with lower education level still had higher overall mortality.
ISSN:2234943X
DOI:10.3389/fonc.2025.1636292