Zobraziť v EDS

Fibrillar deformation mechanisms in rat Achilles tendons are governed by strain rate

Uložené v:
Podrobná bibliografia
Názov: Fibrillar deformation mechanisms in rat Achilles tendons are governed by strain rate
Autori: Sharma, Kunal, Silva Barreto, Isabella, Dejea, Hector, Mota-Santiago, Pablo, Eliasson, Pernilla, Pierantoni, Maria, Isaksson, Hanna
Prispievatelia: Lund University, Faculty of Engineering, LTH, Departments at LTH, Department of Biomedical Engineering, Division for Biomedical Engineering, Lunds universitet, Lunds Tekniska Högskola, Institutioner vid LTH, Institutionen för biomedicinsk teknik, Avdelningen för biomedicinsk teknik, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Engineering Health, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Teknik för hälsa, Originator, Lund University, MAX IV Laboratory, Lunds universitet, MAX IV-laboratoriet, Originator, Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Proactive Ageing, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Proaktivt åldrande, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Orthopaedics (Lund), Building Bone Killing Bugs, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Ortopedi, Lund, Building Bone Killing Bugs, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), NanoLund: Centre for Nanoscience, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), NanoLund: Centre for Nanoscience, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Nanoscience and Semiconductor Technology, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Nanovetenskap och halvledarteknologi, Originator, Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Light and Materials, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Ljus och material, Originator
Zdroj: Acta Biomaterialia Tendon Biomechanics. 204:404-412
Predmety: Engineering and Technology, Materials Engineering, Other Materials Engineering, Teknik, Materialteknik, Annan materialteknik
Popis: Tendons are hierarchically structured and composed of load-bearing collagen. Their hierarchical structure allows the transfer of tensile forces across multiple length scales as loads are partitioned from the whole tendon through fascicles, fibers, and fibrils down to the tropocollagen molecules. To elucidate their structural hierarchical deformation, this study investigated the combined tissue, fibrillar, and molecular response of tendons to in situ tensile load by means of simultaneous small- and wide-angle X-ray scattering. Rat Achilles tendons were loaded at three magnitudes of strain rates in ramp (20, 2, and 0.2 %/s), and 20 %/s in stress-relaxation for 500 s. Hierarchical strain partitioning was found, where in the 20 %/s strain rate group the fibrils were experiencing at most 7 % of the applied tissue strains, and molecules at most 2 %. At low and medium strain rates the fibrils elongated, while at the high strain rate the fibrils both elongated and slid, as observed by increase in d-spacing and decrease in overlap length. During stress relaxation, the fibril and molecular fast relaxation was four times slower compared to the overall tissue response. The fibrillar Poisson's ratios did not appear to change with strain rate. This study highlights how the viscoelastic behavior of tendons extends across length scales and provides further evidence of tendon's strain partitioning and strain-rate dependent deformation mechanisms. Statement of significance: Achilles tendons are exposed to high mechanical loads and are prone to injuries. Due to their hierarchical structure understanding how the loading is taken up by the tissue is complex. However, understanding the hierarchical structural response and its relation to tendon function is crucial to aid in rehabilitation and treatment. We combine the use of synchrotron small- and wide-angle X-ray scattering with simultaneous in situ loading of rat Achilles tendons to understand the relation between the loading of the whole tendon down to the structural adaptations ofthe collagen fibrils and collagen molecules, experienced at the nano- and ångstrom-scale. The proposed methodology aids in understanding the deformation mechanisms occurring during tendon loading and rupture.
Prístupová URL adresa: https://doi.org/10.1016/j.actbio.2025.08.004
Databáza: SwePub
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doi.org/10.1016/j.actbio.2025.08.004#
    Name: EDS - SwePub (s4221598)
    Category: fullText
    Text: View record in SwePub
  – Url: https://resolver.ebscohost.com/openurl?sid=EBSCO:edsswe&genre=article&issn=17427061&ISBN=&volume=204&issue=&date=20250101&spage=404&pages=404-412&title=Acta Biomaterialia Tendon Biomechanics&atitle=Fibrillar%20deformation%20mechanisms%20in%20rat%20Achilles%20tendons%20are%20governed%20by%20strain%20rate&aulast=Sharma%2C%20Kunal&id=DOI:10.1016/j.actbio.2025.08.004
    Name: Full Text Finder
    Category: fullText
    Text: Full Text Finder
    Icon: https://imageserver.ebscohost.com/branding/images/FTF.gif
    MouseOverText: Full Text Finder
  – Url: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=EBSCO&SrcAuth=EBSCO&DestApp=WOS&ServiceName=TransferToWoS&DestLinkType=GeneralSearchSummary&Func=Links&author=Sharma%20K
    Name: ISI
    Category: fullText
    Text: Nájsť tento článok vo Web of Science
    Icon: https://imagesrvr.epnet.com/ls/20docs.gif
    MouseOverText: Nájsť tento článok vo Web of Science
Header DbId: edsswe
DbLabel: SwePub
An: edsswe.oai.portal.research.lu.se.publications.75b0907f.eb4c.4a9f.b6e0.829f353ae873
RelevancyScore: 1115
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1114.736328125
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Fibrillar deformation mechanisms in rat Achilles tendons are governed by strain rate
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Sharma%2C+Kunal%22">Sharma, Kunal</searchLink><br /><searchLink fieldCode="AR" term="%22Silva+Barreto%2C+Isabella%22">Silva Barreto, Isabella</searchLink><br /><searchLink fieldCode="AR" term="%22Dejea%2C+Hector%22">Dejea, Hector</searchLink><br /><searchLink fieldCode="AR" term="%22Mota-Santiago%2C+Pablo%22">Mota-Santiago, Pablo</searchLink><br /><searchLink fieldCode="AR" term="%22Eliasson%2C+Pernilla%22">Eliasson, Pernilla</searchLink><br /><searchLink fieldCode="AR" term="%22Pierantoni%2C+Maria%22">Pierantoni, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Isaksson%2C+Hanna%22">Isaksson, Hanna</searchLink>
– Name: Author
  Label: Contributors
  Group: Au
  Data: Lund University, Faculty of Engineering, LTH, Departments at LTH, Department of Biomedical Engineering, Division for Biomedical Engineering, Lunds universitet, Lunds Tekniska Högskola, Institutioner vid LTH, Institutionen för biomedicinsk teknik, Avdelningen för biomedicinsk teknik, Originator<br />Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Engineering Health, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Teknik för hälsa, Originator<br />Lund University, MAX IV Laboratory, Lunds universitet, MAX IV-laboratoriet, Originator<br />Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Proactive Ageing, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Proaktivt åldrande, Originator<br />Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Orthopaedics (Lund), Building Bone Killing Bugs, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Ortopedi, Lund, Building Bone Killing Bugs, Originator<br />Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), NanoLund: Centre for Nanoscience, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), NanoLund: Centre for Nanoscience, Originator<br />Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Nanoscience and Semiconductor Technology, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Nanovetenskap och halvledarteknologi, Originator<br />Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Light and Materials, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Ljus och material, Originator
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <i>Acta Biomaterialia Tendon Biomechanics</i>. 204:404-412
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Engineering+and+Technology%22">Engineering and Technology</searchLink><br /><searchLink fieldCode="DE" term="%22Materials+Engineering%22">Materials Engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Other+Materials+Engineering%22">Other Materials Engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Teknik%22">Teknik</searchLink><br /><searchLink fieldCode="DE" term="%22Materialteknik%22">Materialteknik</searchLink><br /><searchLink fieldCode="DE" term="%22Annan+materialteknik%22">Annan materialteknik</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Tendons are hierarchically structured and composed of load-bearing collagen. Their hierarchical structure allows the transfer of tensile forces across multiple length scales as loads are partitioned from the whole tendon through fascicles, fibers, and fibrils down to the tropocollagen molecules. To elucidate their structural hierarchical deformation, this study investigated the combined tissue, fibrillar, and molecular response of tendons to in situ tensile load by means of simultaneous small- and wide-angle X-ray scattering. Rat Achilles tendons were loaded at three magnitudes of strain rates in ramp (20, 2, and 0.2 %/s), and 20 %/s in stress-relaxation for 500 s. Hierarchical strain partitioning was found, where in the 20 %/s strain rate group the fibrils were experiencing at most 7 % of the applied tissue strains, and molecules at most 2 %. At low and medium strain rates the fibrils elongated, while at the high strain rate the fibrils both elongated and slid, as observed by increase in d-spacing and decrease in overlap length. During stress relaxation, the fibril and molecular fast relaxation was four times slower compared to the overall tissue response. The fibrillar Poisson's ratios did not appear to change with strain rate. This study highlights how the viscoelastic behavior of tendons extends across length scales and provides further evidence of tendon's strain partitioning and strain-rate dependent deformation mechanisms. Statement of significance: Achilles tendons are exposed to high mechanical loads and are prone to injuries. Due to their hierarchical structure understanding how the loading is taken up by the tissue is complex. However, understanding the hierarchical structural response and its relation to tendon function is crucial to aid in rehabilitation and treatment. We combine the use of synchrotron small- and wide-angle X-ray scattering with simultaneous in situ loading of rat Achilles tendons to understand the relation between the loading of the whole tendon down to the structural adaptations ofthe collagen fibrils and collagen molecules, experienced at the nano- and ångstrom-scale. The proposed methodology aids in understanding the deformation mechanisms occurring during tendon loading and rupture.
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doi.org/10.1016/j.actbio.2025.08.004" linkWindow="_blank">https://doi.org/10.1016/j.actbio.2025.08.004</link>
PLink https://erproxy.cvtisr.sk/sfx/access?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsswe&AN=edsswe.oai.portal.research.lu.se.publications.75b0907f.eb4c.4a9f.b6e0.829f353ae873
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.actbio.2025.08.004
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 404
    Subjects:
      – SubjectFull: Engineering and Technology
        Type: general
      – SubjectFull: Materials Engineering
        Type: general
      – SubjectFull: Other Materials Engineering
        Type: general
      – SubjectFull: Teknik
        Type: general
      – SubjectFull: Materialteknik
        Type: general
      – SubjectFull: Annan materialteknik
        Type: general
    Titles:
      – TitleFull: Fibrillar deformation mechanisms in rat Achilles tendons are governed by strain rate
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sharma, Kunal
      – PersonEntity:
          Name:
            NameFull: Silva Barreto, Isabella
      – PersonEntity:
          Name:
            NameFull: Dejea, Hector
      – PersonEntity:
          Name:
            NameFull: Mota-Santiago, Pablo
      – PersonEntity:
          Name:
            NameFull: Eliasson, Pernilla
      – PersonEntity:
          Name:
            NameFull: Pierantoni, Maria
      – PersonEntity:
          Name:
            NameFull: Isaksson, Hanna
      – PersonEntity:
          Name:
            NameFull: Lund University, Faculty of Engineering, LTH, Departments at LTH, Department of Biomedical Engineering, Division for Biomedical Engineering, Lunds universitet, Lunds Tekniska Högskola, Institutioner vid LTH, Institutionen för biomedicinsk teknik, Avdelningen för biomedicinsk teknik, Originator
      – PersonEntity:
          Name:
            NameFull: Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Engineering Health, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Teknik för hälsa, Originator
      – PersonEntity:
          Name:
            NameFull: Lund University, MAX IV Laboratory, Lunds universitet, MAX IV-laboratoriet, Originator
      – PersonEntity:
          Name:
            NameFull: Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Proactive Ageing, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Proaktivt åldrande, Originator
      – PersonEntity:
          Name:
            NameFull: Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Orthopaedics (Lund), Building Bone Killing Bugs, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Ortopedi, Lund, Building Bone Killing Bugs, Originator
      – PersonEntity:
          Name:
            NameFull: Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), NanoLund: Centre for Nanoscience, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), NanoLund: Centre for Nanoscience, Originator
      – PersonEntity:
          Name:
            NameFull: Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Nanoscience and Semiconductor Technology, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Nanovetenskap och halvledarteknologi, Originator
      – PersonEntity:
          Name:
            NameFull: Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Light and Materials, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Ljus och material, Originator
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 17427061
            – Type: issn-locals
              Value: SWEPUB_FREE
            – Type: issn-locals
              Value: LU_SWEPUB
          Numbering:
            – Type: volume
              Value: 204
          Titles:
            – TitleFull: Acta Biomaterialia Tendon Biomechanics
              Type: main
ResultId 1