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The joint effects of genetic liability and the death of close relatives on risk for major depression and alcohol use disorder in a Swedish national sample

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Titel: The joint effects of genetic liability and the death of close relatives on risk for major depression and alcohol use disorder in a Swedish national sample
Autoren: Kendler, Kenneth S., Lönn, Sara L., Sundquist, Jan, Sundquist, Kristina
Weitere Verfasser: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Family Medicine and Clinical Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Allmänmedicin och klinisk epidemiologi, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator
Quelle: Psychological Medicine. 54(8):1709-1716
Schlagwörter: Medical and Health Sciences, Health Sciences, Drug Abuse and Addiction, Medicin och hälsovetenskap, Hälsovetenskap, Beroendelära och missbruk
Beschreibung: Background. To determine whether genetic risk factors for major depression (MD) and alcohol use disorder (AUD) interact with a potent stressor – death of spouse, parent, and sibling – in predicting episodes of, respectively, MD and AUD. Methods. MD and AUD registrations were assessed from national Swedish registries. In individuals born in Sweden 1960–1970, we identified 7586, 388 459, and 34 370 with the loss of, respectively, a spouse, parent, and sibling. We started following subjects at age 18 or the year 2002 with end of follow-up in 2018. We examined time to event – a registration for MD within 6 months or AUD within a year – on an additive scale, using the Nelson–Aalen estimator. Genetic risk was assessed by the Family Genetic Risk Score (FGRS). Results. In separate models controlling for the main effects of death of spouse, parent, and sibling, FGRS, and sex, significant interactions were seen in all analyses between genetic risk for MD and death of relative in prediction of subsequent MD registration. A similar pattern of results, albeit with weaker interaction effects, was seen for genetic risk for AUD and risk for AUD registration. Genetic risk for bipolar disorder (BD) and anxiety disorders (AD) also interacted with event exposure in predicting MD. Conclusions. Genetic risk for both MD and AUD act in part by increasing the sensitivity of individuals to the pathogenic effects of environmental stressors. For prediction of MD, similar effects are also seen for genetic risk for AD and BD.
Zugangs-URL: https://doi.org/10.1017/S0033291723003641
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  Data: The joint effects of genetic liability and the death of close relatives on risk for major depression and alcohol use disorder in a Swedish national sample
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  Data: <searchLink fieldCode="AR" term="%22Kendler%2C+Kenneth+S%2E%22">Kendler, Kenneth S.</searchLink><br /><searchLink fieldCode="AR" term="%22Lönn%2C+Sara+L%2E%22">Lönn, Sara L.</searchLink><br /><searchLink fieldCode="AR" term="%22Sundquist%2C+Jan%22">Sundquist, Jan</searchLink><br /><searchLink fieldCode="AR" term="%22Sundquist%2C+Kristina%22">Sundquist, Kristina</searchLink>
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  Data: Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Family Medicine and Clinical Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Allmänmedicin och klinisk epidemiologi, Originator<br />Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator
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  Data: <i>Psychological Medicine</i>. 54(8):1709-1716
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  Data: <searchLink fieldCode="DE" term="%22Medical+and+Health+Sciences%22">Medical and Health Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Health+Sciences%22">Health Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+Abuse+and+Addiction%22">Drug Abuse and Addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Medicin+och+hälsovetenskap%22">Medicin och hälsovetenskap</searchLink><br /><searchLink fieldCode="DE" term="%22Hälsovetenskap%22">Hälsovetenskap</searchLink><br /><searchLink fieldCode="DE" term="%22Beroendelära+och+missbruk%22">Beroendelära och missbruk</searchLink>
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  Label: Description
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  Data: Background. To determine whether genetic risk factors for major depression (MD) and alcohol use disorder (AUD) interact with a potent stressor – death of spouse, parent, and sibling – in predicting episodes of, respectively, MD and AUD. Methods. MD and AUD registrations were assessed from national Swedish registries. In individuals born in Sweden 1960–1970, we identified 7586, 388 459, and 34 370 with the loss of, respectively, a spouse, parent, and sibling. We started following subjects at age 18 or the year 2002 with end of follow-up in 2018. We examined time to event – a registration for MD within 6 months or AUD within a year – on an additive scale, using the Nelson–Aalen estimator. Genetic risk was assessed by the Family Genetic Risk Score (FGRS). Results. In separate models controlling for the main effects of death of spouse, parent, and sibling, FGRS, and sex, significant interactions were seen in all analyses between genetic risk for MD and death of relative in prediction of subsequent MD registration. A similar pattern of results, albeit with weaker interaction effects, was seen for genetic risk for AUD and risk for AUD registration. Genetic risk for bipolar disorder (BD) and anxiety disorders (AD) also interacted with event exposure in predicting MD. Conclusions. Genetic risk for both MD and AUD act in part by increasing the sensitivity of individuals to the pathogenic effects of environmental stressors. For prediction of MD, similar effects are also seen for genetic risk for AD and BD.
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