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Sustainable Synthesis of Trimethylolpropane, a Biobased Polyol from Renewable Resources by an Integrated Process of Biotechnology and Chemical Reactions

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Title: Sustainable Synthesis of Trimethylolpropane, a Biobased Polyol from Renewable Resources by an Integrated Process of Biotechnology and Chemical Reactions
Authors: Sayed, Mahmoud, Elsabaa, Hossameldeen, Han, Jian, Choi, Jinsik, Sayed, Waiel F., Salem, Wesam M., Temerk, Hanan A., Xu, Yong, Pyo, Sang-Hyun
Contributors: Lund University, Faculty of Engineering, LTH, Departments at LTH, Department of Process and Life Science Engineering, Division of Biotechnology and Applied Microbiology, Lunds universitet, Lunds Tekniska Högskola, Institutioner vid LTH, Institutionen för processteknik och tillämpad biovetenskap, Avdelningen för bioteknik och teknisk mikrobiologi, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Food and Bio, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Livsmedel och bioteknik, Originator
Source: ACS Omega. 10(29):32413-32423
Subject Terms: Engineering and Technology, Industrial Biotechnology, Teknik, Industriell bioteknik
Description: Trimethylolpropane (TMP) is an important industrial chemical used to produce various value-added chemicals and polymers. In this study, both biobased butyraldehyde and formaldehyde were produced by the incomplete oxidation of bio-1-butanol and biomethanol, respectively, and were then used to produce a biobased TMP. High selective incomplete oxidation of primary alcohol to aldehyde is a challenging process minimizing the corresponding carboxylic acid, a complete oxidation product. Guconobactor oxidans DSM 2343 was found to have high activity and selectivity for the oxidation of butanol to butyraldehyde by whole-cell biotransformation. A pH 5 and greater than 15 g/L of 1-butanol are preferable conditions for butyraldehyde accumulation. In a 1 L bioreactor experiment, 18 g/L of bio-1-butanol was oxidized to 13 g/L of butyraldehyde at an 85% conversion and 93% selectivity. Biomethanol oxidation to formaldehyde was conducted at relatively high concentration using alcohol oxidase from Pichia pastoris. After 48 h ofenzymatic reaction, a 52% conversion of 5.5 g/L biomethanol to 2.6 g/L formaldehyde at 100% selectivity without byproduct was achieved. Using the resulting butyraldehyde and formaldehyde, TMP could be produced through aldol and Cannizzaro reactions under basic conditions. The overall process shows a new synthetic route for TMP production that uses renewable resources and integrates both biotechnology and chemical processes.
Access URL: https://doi.org/10.1021/acsomega.5c04762
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  Data: Sustainable Synthesis of Trimethylolpropane, a Biobased Polyol from Renewable Resources by an Integrated Process of Biotechnology and Chemical Reactions
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  Data: Trimethylolpropane (TMP) is an important industrial chemical used to produce various value-added chemicals and polymers. In this study, both biobased butyraldehyde and formaldehyde were produced by the incomplete oxidation of bio-1-butanol and biomethanol, respectively, and were then used to produce a biobased TMP. High selective incomplete oxidation of primary alcohol to aldehyde is a challenging process minimizing the corresponding carboxylic acid, a complete oxidation product. Guconobactor oxidans DSM 2343 was found to have high activity and selectivity for the oxidation of butanol to butyraldehyde by whole-cell biotransformation. A pH 5 and greater than 15 g/L of 1-butanol are preferable conditions for butyraldehyde accumulation. In a 1 L bioreactor experiment, 18 g/L of bio-1-butanol was oxidized to 13 g/L of butyraldehyde at an 85% conversion and 93% selectivity. Biomethanol oxidation to formaldehyde was conducted at relatively high concentration using alcohol oxidase from Pichia pastoris. After 48 h ofenzymatic reaction, a 52% conversion of 5.5 g/L biomethanol to 2.6 g/L formaldehyde at 100% selectivity without byproduct was achieved. Using the resulting butyraldehyde and formaldehyde, TMP could be produced through aldol and Cannizzaro reactions under basic conditions. The overall process shows a new synthetic route for TMP production that uses renewable resources and integrates both biotechnology and chemical processes.
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