Increased prevalence of osteopenia and osteoporosis in systemic sclerosis patients, including in men and young women—a case–control study
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| Názov: | Increased prevalence of osteopenia and osteoporosis in systemic sclerosis patients, including in men and young women—a case–control study |
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| Autori: | Lillpers, Kerstin, Mcguigan, Fiona, Andréasson, Kristofer, Hesselstrand, Roger, C Kapetanovic, Meliha, Åkesson, Kristina |
| Prispievatelia: | Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Orthopedics, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Ortopedi, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Rheumatology, Lund Systemic Sclerosis Research Group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Reumatologi och molekylär skelettbiologi, Forskargruppen för systemisk skleros, Lund, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section II, Thoracic Surgery, Cardiopulmonary disease - information, support and reception, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion II, Thoraxkirurgi, Hjärt-lungsjukdom - information, stöd och bemötande, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Rheumatology, Lund Arthritis Research Group (LARG), Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Reumatologi och molekylär skelettbiologi, Lund Arthritis Research Group (LARG), Originator |
| Zdroj: | Rheumatology (Oxford, England). 64(5):2783-2791 |
| Predmety: | Medical and Health Sciences, Clinical Medicine, Orthopaedics, Medicin och hälsovetenskap, Klinisk medicin, Ortopedi, Basic Medicine, Epidemiology, Medicinska och farmaceutiska grundvetenskaper, Epidemiologi |
| Popis: | Objectives To investigate bone mineral density (BMD), osteoporosis prevalence and SSc-specific associations of BMD in SSc patients compared with background population. Methods In total, 211 SSc patients (182 women, 29 men; mean age 61.3 and 62.2 years, respectively) and 505 age- and sex-matched controls from the same geographic area participated. BMD and T-score at total hip and lumbar spine was measured by dual-energy X-ray absorptiometry. Osteopenia was defined as T-score –1.0 to –2.5, and osteoporosis as T-score ≤–2.5. Associates of low BMD were identified by multiple regression analysis. Results Women with SSc had lower BMD for total hip (P < 0.001) and spine (P = 0.011), equivalent to ΔT-score –0.56 and –0.35 compared with controls. Osteopenia was present in 51.6% and 16.5% had osteoporosis (P = 0.001, compared with controls). Already in women below age 45 years, differences in hip BMD were apparent (ΔT-score –0.93, P = 0.005). In addition to expected risk factors for osteoporosis (older age, lower BMI and menopause), finger ulcers (P = 0.009) and diffuse skin involvement (P = 0.027) were associated with lower hip BMD in women. In men with SSc, more than half displayed osteopenia or osteoporosis and had numerically lower hip BMD than their age-matched counterparts. Conclusion SSc patients, including men and younger women, have lower BMD than the background population. Finger ulcers and diffuse skin involvement, in addition to older age, lower BMI and being post-menopausal, are associated with lower BMD in women. The data emphasize the importance of performing bone health assessment of all SSc patients, including men and young subjects. |
| Prístupová URL adresa: | https://doi.org/10.1093/rheumatology/keae543 |
| Databáza: | SwePub |
Nájsť tento článok vo Web of Science | Abstrakt: | Objectives To investigate bone mineral density (BMD), osteoporosis prevalence and SSc-specific associations of BMD in SSc patients compared with background population. Methods In total, 211 SSc patients (182 women, 29 men; mean age 61.3 and 62.2 years, respectively) and 505 age- and sex-matched controls from the same geographic area participated. BMD and T-score at total hip and lumbar spine was measured by dual-energy X-ray absorptiometry. Osteopenia was defined as T-score –1.0 to –2.5, and osteoporosis as T-score ≤–2.5. Associates of low BMD were identified by multiple regression analysis. Results Women with SSc had lower BMD for total hip (P < 0.001) and spine (P = 0.011), equivalent to ΔT-score –0.56 and –0.35 compared with controls. Osteopenia was present in 51.6% and 16.5% had osteoporosis (P = 0.001, compared with controls). Already in women below age 45 years, differences in hip BMD were apparent (ΔT-score –0.93, P = 0.005). In addition to expected risk factors for osteoporosis (older age, lower BMI and menopause), finger ulcers (P = 0.009) and diffuse skin involvement (P = 0.027) were associated with lower hip BMD in women. In men with SSc, more than half displayed osteopenia or osteoporosis and had numerically lower hip BMD than their age-matched counterparts. Conclusion SSc patients, including men and younger women, have lower BMD than the background population. Finger ulcers and diffuse skin involvement, in addition to older age, lower BMI and being post-menopausal, are associated with lower BMD in women. The data emphasize the importance of performing bone health assessment of all SSc patients, including men and young subjects. |
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| ISSN: | 14620324 14620332 |
| DOI: | 10.1093/rheumatology/keae543 |