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Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study

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Název: Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study
Autoři: Liljedahl, Emelie Rietz, Gliga, Anda, de Paula, Helena Korres, Engfeldt, Malin, Julander, Anneli, Lidén, Carola, Lindh, Christian, Broberg, Karin
Přispěvatelé: Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Epidemiologi, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Applied Mass Spectrometry in Environmental Medicine, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Tillämpad masspektrometri inom miljömedicin, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Genetic Occupational and Environmental Medicine, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Genetisk arbets- och miljömedicin, Originator, Lund University, Faculty of Engineering, LTH, Other operations, LTH, Metalund, Lunds universitet, Lunds Tekniska Högskola, Annan verksamhet, LTH, Metalund, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Occupational and Environmental Dermatology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Yrkes- och miljödermatologi, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Aerosols, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Aerosoler, Originator
Zdroj: Environmental Toxicology and Pharmacology. 105
Témata: Agricultural and Veterinary sciences, Other Agricultural Sciences, Other Agricultural Sciences not elsewhere specified, Lantbruksvetenskap och veterinärmedicin, Annan lantbruksvetenskap, Övrig annan lantbruksvetenskap
Popis: Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22 proteins among wt carriers (three proteins overlapped). Twelve proteins showed median differences (post- vs pre-exposure) between FLG null and wt carriers. Overall, FLG null carriers showed an increase, while FLG wt carriers showed a decrease in inflammation-related proteins. These findings suggest FLG-dependent differences in susceptibility to systemic effects following simultaneous dermal chemical exposure.
Přístupová URL adresa: https://doi.org/10.1016/j.etap.2023.104346
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  Data: Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study
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  Data: Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Originator<br />Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Epidemiology, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Epidemiologi, Originator<br />Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Applied Mass Spectrometry in Environmental Medicine, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Tillämpad masspektrometri inom miljömedicin, Originator<br />Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Genetic Occupational and Environmental Medicine, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för arbets- och miljömedicin, Genetisk arbets- och miljömedicin, Originator<br />Lund University, Faculty of Engineering, LTH, Other operations, LTH, Metalund, Lunds universitet, Lunds Tekniska Högskola, Annan verksamhet, LTH, Metalund, Originator<br />Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Occupational and Environmental Dermatology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Yrkes- och miljödermatologi, Originator<br />Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator<br />Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Aerosols, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Aerosoler, Originator
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  Data: <i>Environmental Toxicology and Pharmacology</i>. 105
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  Data: Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22 proteins among wt carriers (three proteins overlapped). Twelve proteins showed median differences (post- vs pre-exposure) between FLG null and wt carriers. Overall, FLG null carriers showed an increase, while FLG wt carriers showed a decrease in inflammation-related proteins. These findings suggest FLG-dependent differences in susceptibility to systemic effects following simultaneous dermal chemical exposure.
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