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Developing a novel predictive model for identifying risk factors associated with being lost to follow-up among high-risk patients for recurrence following radical resection of hepatocellular carcinoma: the first report

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Názov: Developing a novel predictive model for identifying risk factors associated with being lost to follow-up among high-risk patients for recurrence following radical resection of hepatocellular carcinoma: the first report
Autori: Zichen Yu, Wenli Cao, Chengfei Du, Jie Liu, Liping Peng, Fangqiang Wei
Zdroj: BMC Cancer, Vol 25, Iss 1, Pp 1-14 (2025)
Informácie o vydavateľovi: BMC, 2025.
Rok vydania: 2025
Zbierka: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Predmety: Hepatocellular carcinoma, Radical resection, Lost to follow-up, Recurrence, Model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Popis: Abstract Background Follow-up is essential especially for patients who are at a high risk of recurrence after radical resection of hepatocellular carcinoma (HCC). The aim of this study was to develop a predictive model aimed at identifying the risk factors associated with being lost to follow-up (LTFU) in high-risk patients for recurrence following radical resection of HCC. Methods The retrospective study was conducted at our institution between October 2018 to May 2023. The patients who underwent radical liver resection for HCC and had high-risk factors for recurrence were categorized into an LTFU group and a control group. Multivariate logistic regression analysis was utilized to determine risk factors and construct a nomogram predictive model. Results A total of 352 patients were included and subsequently classified into two distinct groups: the LTFU group (n = 123, 34.94%) and the control group (n = 229, 65.06%). Logistic regression analysis was then conducted to explore the potential associations between various factors and the occurrence of LTFU. The findings identified several independent risk factors for LTFU, including smoking (odds ratio, OR = 1.823, 95% confidence interval, CI 1.086–3.060, p = 0.023); residing more than 200 km away from the hospital (OR = 1.857, 95% CI 1.105–3.121, p = 0.019); having an unstable profession (OR = 1.918, 95% CI 1.112–3.311, p = 0.019); and lacking medical insurance (OR = 5.921, 95% CI 1.747–20.071, p = 0.004); the presence of liver cirrhosis (OR = 2.161, 95% CI 1.153–4.048, p = 0.016); an operation time less than 240 min (OR = 2.138, 95% CI 1.240–3.688, p = 0.006); and the absence of postoperative adjuvant therapy (OR = 2.641, 95% CI 1.504–4.637, p = 0.001). Based on these seven significant factors, a main effects model was established, designated as the Wei-LTFU model, which achieved an area under the curve value of 0.744 (95% CI 0.691–0.798) in predicting the likelihood of LTFU. Conclusion A main effects model, namely the Wei-LTFU model, incorporating the seven significant factors was formulated to predict the likelihood of LTFU occurrence, ultimately aiming to assist healthcare workers in developing effective strategies to improve follow-up outcomes for patients.
Druh dokumentu: article
Popis súboru: electronic resource
Jazyk: English
ISSN: 1471-2407
Relation: https://doaj.org/toc/1471-2407
DOI: 10.1186/s12885-025-14030-1
Prístupová URL adresa: https://doaj.org/article/ce6c07eec8d94e0aa1beae4dbfec14d5
Prístupové číslo: edsdoj.6c07eec8d94e0aa1beae4dbfec14d5
Databáza: Directory of Open Access Journals
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  Data: Developing a novel predictive model for identifying risk factors associated with being lost to follow-up among high-risk patients for recurrence following radical resection of hepatocellular carcinoma: the first report
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  Data: <searchLink fieldCode="AR" term="%22Zichen+Yu%22">Zichen Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Wenli+Cao%22">Wenli Cao</searchLink><br /><searchLink fieldCode="AR" term="%22Chengfei+Du%22">Chengfei Du</searchLink><br /><searchLink fieldCode="AR" term="%22Jie+Liu%22">Jie Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Liping+Peng%22">Liping Peng</searchLink><br /><searchLink fieldCode="AR" term="%22Fangqiang+Wei%22">Fangqiang Wei</searchLink>
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  Data: BMC Cancer, Vol 25, Iss 1, Pp 1-14 (2025)
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  Data: <searchLink fieldCode="DE" term="%22Hepatocellular+carcinoma%22">Hepatocellular carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Radical+resection%22">Radical resection</searchLink><br /><searchLink fieldCode="DE" term="%22Lost+to+follow-up%22">Lost to follow-up</searchLink><br /><searchLink fieldCode="DE" term="%22Recurrence%22">Recurrence</searchLink><br /><searchLink fieldCode="DE" term="%22Model%22">Model</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplasms%2E+Tumors%2E+Oncology%2E+Including+cancer+and+carcinogens%22">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</searchLink><br /><searchLink fieldCode="DE" term="%22RC254-282%22">RC254-282</searchLink>
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  Label: Description
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  Data: Abstract Background Follow-up is essential especially for patients who are at a high risk of recurrence after radical resection of hepatocellular carcinoma (HCC). The aim of this study was to develop a predictive model aimed at identifying the risk factors associated with being lost to follow-up (LTFU) in high-risk patients for recurrence following radical resection of HCC. Methods The retrospective study was conducted at our institution between October 2018 to May 2023. The patients who underwent radical liver resection for HCC and had high-risk factors for recurrence were categorized into an LTFU group and a control group. Multivariate logistic regression analysis was utilized to determine risk factors and construct a nomogram predictive model. Results A total of 352 patients were included and subsequently classified into two distinct groups: the LTFU group (n = 123, 34.94%) and the control group (n = 229, 65.06%). Logistic regression analysis was then conducted to explore the potential associations between various factors and the occurrence of LTFU. The findings identified several independent risk factors for LTFU, including smoking (odds ratio, OR = 1.823, 95% confidence interval, CI 1.086–3.060, p = 0.023); residing more than 200 km away from the hospital (OR = 1.857, 95% CI 1.105–3.121, p = 0.019); having an unstable profession (OR = 1.918, 95% CI 1.112–3.311, p = 0.019); and lacking medical insurance (OR = 5.921, 95% CI 1.747–20.071, p = 0.004); the presence of liver cirrhosis (OR = 2.161, 95% CI 1.153–4.048, p = 0.016); an operation time less than 240 min (OR = 2.138, 95% CI 1.240–3.688, p = 0.006); and the absence of postoperative adjuvant therapy (OR = 2.641, 95% CI 1.504–4.637, p = 0.001). Based on these seven significant factors, a main effects model was established, designated as the Wei-LTFU model, which achieved an area under the curve value of 0.744 (95% CI 0.691–0.798) in predicting the likelihood of LTFU. Conclusion A main effects model, namely the Wei-LTFU model, incorporating the seven significant factors was formulated to predict the likelihood of LTFU occurrence, ultimately aiming to assist healthcare workers in developing effective strategies to improve follow-up outcomes for patients.
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    Subjects:
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        Type: general
      – SubjectFull: Radical resection
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      – SubjectFull: Lost to follow-up
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      – TitleFull: Developing a novel predictive model for identifying risk factors associated with being lost to follow-up among high-risk patients for recurrence following radical resection of hepatocellular carcinoma: the first report
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