Plasma Arginine Vasopressin and Serum Copeptin Concentrations at Rest and After Osmotic‐ and Non‐Osmotic‐Based Stimulation Tests in Dogs
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| Titel: | Plasma Arginine Vasopressin and Serum Copeptin Concentrations at Rest and After Osmotic‐ and Non‐Osmotic‐Based Stimulation Tests in Dogs |
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| Autoren: | Mathieu Victor Paulin, Thomas Schermerhorn, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth Snead |
| Quelle: | Journal of Veterinary Internal Medicine, Vol 39, Iss 5, Pp n/a-n/a (2025) |
| Verlagsinformationen: | Wiley, 2025. |
| Publikationsjahr: | 2025 |
| Bestand: | LCC:Veterinary medicine |
| Schlagwörter: | ADH, anti‐diuretic hormone, AVP, desmopressin, PUPD, water metabolism, Veterinary medicine, SF600-1100 |
| Beschreibung: | ABSTRACT Background Serum copeptin (sCoP) is used as a surrogate for plasma arginine vasopressin (pAVP) measurement in humans. Objective To measure pAVP and sCoP at rest and after osmotic‐ and non‐osmotic stimulation testing in dogs. Animals Eight young castrated/spayed healthy research Beagles, eight young intact dogs, and eight old neutered healthy client‐owned dogs. Methods In this prospective longitudinal study, pAVP and sCoP were measured under iso‐(baseline), hypo‐(water load followed by intravenous administration of desmopressin [WLT]), and hyper‐(water deprivation test [WDT]) osmolar conditions assessed by measured plasma osmolality (pOsm(m)), and after administration of arginine (AST), IV, and Bovril (BST), PO. The fraction of change (F) in a variable y (e.g., pAVP) between baseline (T0) and a timepoint X (TX) during testing was defined as Fy = [y (TX) – y (T0)]/y (T0). Results Baseline sCoP had wide inter‐individual variations. Mean [range] FpAVP and FsCoP at the end of WDT were +110% [+80; +142] and +18% [+0.4; +38] compared to baseline, respectively. Mean [range] FpAVP after water load and FsCoP after water load followed by desmopressin administration were −22% [−48; −0.5] and −29% [−39; −14] compared to baseline, respectively. Both FpAVP and FsCoP were strongly correlated to FpOsm(m) (r = +0.76, p = 0.004; r = +0.78, p = 0.002; respectively). When sCoP was measured at T4h instead of T2h during WLT, to reflect its longer half‐life reported in humans, the correlation between FpAVPP800 and FsCoP became excellent (r = +0.90, p |
| Publikationsart: | article |
| Dateibeschreibung: | electronic resource |
| Sprache: | English |
| ISSN: | 1939-1676 0891-6640 |
| Relation: | https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676 |
| DOI: | 10.1111/jvim.70219 |
| Zugangs-URL: | https://doaj.org/article/5e22c4e071ba4dde87cbd9f085d36de7 |
| Dokumentencode: | edsdoj.5e22c4e071ba4dde87cbd9f085d36de7 |
| Datenbank: | Directory of Open Access Journals |
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| Abstract: | ABSTRACT Background Serum copeptin (sCoP) is used as a surrogate for plasma arginine vasopressin (pAVP) measurement in humans. Objective To measure pAVP and sCoP at rest and after osmotic‐ and non‐osmotic stimulation testing in dogs. Animals Eight young castrated/spayed healthy research Beagles, eight young intact dogs, and eight old neutered healthy client‐owned dogs. Methods In this prospective longitudinal study, pAVP and sCoP were measured under iso‐(baseline), hypo‐(water load followed by intravenous administration of desmopressin [WLT]), and hyper‐(water deprivation test [WDT]) osmolar conditions assessed by measured plasma osmolality (pOsm(m)), and after administration of arginine (AST), IV, and Bovril (BST), PO. The fraction of change (F) in a variable y (e.g., pAVP) between baseline (T0) and a timepoint X (TX) during testing was defined as Fy = [y (TX) – y (T0)]/y (T0). Results Baseline sCoP had wide inter‐individual variations. Mean [range] FpAVP and FsCoP at the end of WDT were +110% [+80; +142] and +18% [+0.4; +38] compared to baseline, respectively. Mean [range] FpAVP after water load and FsCoP after water load followed by desmopressin administration were −22% [−48; −0.5] and −29% [−39; −14] compared to baseline, respectively. Both FpAVP and FsCoP were strongly correlated to FpOsm(m) (r = +0.76, p = 0.004; r = +0.78, p = 0.002; respectively). When sCoP was measured at T4h instead of T2h during WLT, to reflect its longer half‐life reported in humans, the correlation between FpAVPP800 and FsCoP became excellent (r = +0.90, p |
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| ISSN: | 19391676 08916640 |
| DOI: | 10.1111/jvim.70219 |