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Exploring the role of oral bacteria in oral cancer: a narrative review

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Title: Exploring the role of oral bacteria in oral cancer: a narrative review
Authors: Hassan Mivehchi, Aisan Eskandari-Yaghbastlo, Parnian Pour Bahrami, Anis Elhami, Farbod Faghihinia, Seyedeh Tabasom Nejati, Kimia Sadat Kazemi, Mohsen Nabi Afjadi
Source: Discover Oncology, Vol 16, Iss 1, Pp 1-24 (2025)
Publisher Information: Springer, 2025.
Publication Year: 2025
Collection: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms: Oral Microbiome, Oral cancer, Porphyromonas gingivalis, Fusobacterium nucleatum, Clostridium spp, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Description: Abstract A growing body of research indicates that a wide range of cancer types may correlate with human microbiome components. On the other hand, little is known about the potential contribution of the oral microbiota to oral cancer. However, some oral microbiome components can stimulate different tumorigenic processes associated with the development of cancer. In this line, two prevalent oral infections, Porphyromonas gingivalis, and Fusobacterium nucleatum can increase tumor growth. The microbiome can impact the course of the illness through direct interactions with the human body and major modifications to the toxicity and responsiveness to different kinds of cancer therapy. Recent research has demonstrated a relationship between specific phylogenetic groupings and the results of immunotherapy treatment for particular tumor types. Conversely, there has been a recent upsurge in interest in the possibility of using microbes to treat cancer. At the moment, some species, such as Salmonella typhimurium and Clostridium spp., are being explored as possible cancer treatment vectors. Thus, understanding these microbial interactions highlights the importance of maintaining a healthy oral microbiome in preventing oral cancers. From this perspective, this review will discuss the role of the microbiome on oral cancers and their possible application in oral cancer treatment/improvement.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2730-6011
Relation: https://doaj.org/toc/2730-6011
DOI: 10.1007/s12672-025-01998-2
Access URL: https://doaj.org/article/520c780d0da24f0380c175b65a19a89c
Accession Number: edsdoj.520c780d0da24f0380c175b65a19a89c
Database: Directory of Open Access Journals
Description
Abstract:Abstract A growing body of research indicates that a wide range of cancer types may correlate with human microbiome components. On the other hand, little is known about the potential contribution of the oral microbiota to oral cancer. However, some oral microbiome components can stimulate different tumorigenic processes associated with the development of cancer. In this line, two prevalent oral infections, Porphyromonas gingivalis, and Fusobacterium nucleatum can increase tumor growth. The microbiome can impact the course of the illness through direct interactions with the human body and major modifications to the toxicity and responsiveness to different kinds of cancer therapy. Recent research has demonstrated a relationship between specific phylogenetic groupings and the results of immunotherapy treatment for particular tumor types. Conversely, there has been a recent upsurge in interest in the possibility of using microbes to treat cancer. At the moment, some species, such as Salmonella typhimurium and Clostridium spp., are being explored as possible cancer treatment vectors. Thus, understanding these microbial interactions highlights the importance of maintaining a healthy oral microbiome in preventing oral cancers. From this perspective, this review will discuss the role of the microbiome on oral cancers and their possible application in oral cancer treatment/improvement.
ISSN:27306011
DOI:10.1007/s12672-025-01998-2