Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice
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| Název: | Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice |
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| Autoři: | Bingqi Li, Xiaofei Zeng, Jing Jiang, Qian Zhou, Li Tong, Xi Liang, Jiaojiao Xin, Xi Chen, Xiao Wu, Yuheng Kong, Shiwen Ma, Jinjin Luo, Wei Qiang, Bing Zhu, Xinhua Luo, Jun Li, Dongyan Shi |
| Zdroj: | Stem Cell Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2025) |
| Informace o vydavateli: | BMC, 2025. |
| Rok vydání: | 2025 |
| Sbírka: | LCC:Medicine (General) LCC:Biochemistry |
| Témata: | Trained immunity, Bone marrow mesenchymal stem cells, Immune microenvironment, Fulminant hepatic failure, Medicine (General), R5-920, Biochemistry, QD415-436 |
| Popis: | Abstract Background Trained immunity with human bone marrow mesenchymal stem cells (hBMSC) is a promising approach to liver regeneration. This study aimed to clarify the trained-hBMSC (T-hBMSC) in restoring tissue immuno-microenvironment in fulminant hepatic failure (FHF) mice. Methods hBMSC trained with tumor necrosis factor-α and interferon-γ were phenotypically characterized in vitro. FHF mouse models were established in male Balb/c mice via tail vein injection of concanavalin A. The therapeutic potential of T-hBMSC was evaluated through transplantation into FHF mice. Transcriptomic analysis was performed to elucidate the mechanism of liver regeneration post-transplantation of T-hBMSC. Results T-hBMSC with the characteristics of trilineage differentiation potential showed that pro-inflammatory (IL1β, IL8, both p |
| Druh dokumentu: | article |
| Popis souboru: | electronic resource |
| Jazyk: | English |
| ISSN: | 1757-6512 |
| Relation: | https://doaj.org/toc/1757-6512 |
| DOI: | 10.1186/s13287-025-04540-x |
| Přístupová URL adresa: | https://doaj.org/article/a41fca5d6f044cce9f8ed22cad78c816 |
| Přístupové číslo: | edsdoj.41fca5d6f044cce9f8ed22cad78c816 |
| Databáze: | Directory of Open Access Journals |
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