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Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice

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Title: Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice
Authors: Bingqi Li, Xiaofei Zeng, Jing Jiang, Qian Zhou, Li Tong, Xi Liang, Jiaojiao Xin, Xi Chen, Xiao Wu, Yuheng Kong, Shiwen Ma, Jinjin Luo, Wei Qiang, Bing Zhu, Xinhua Luo, Jun Li, Dongyan Shi
Source: Stem Cell Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2025)
Publisher Information: BMC, 2025.
Publication Year: 2025
Collection: LCC:Medicine (General)
LCC:Biochemistry
Subject Terms: Trained immunity, Bone marrow mesenchymal stem cells, Immune microenvironment, Fulminant hepatic failure, Medicine (General), R5-920, Biochemistry, QD415-436
Description: Abstract Background Trained immunity with human bone marrow mesenchymal stem cells (hBMSC) is a promising approach to liver regeneration. This study aimed to clarify the trained-hBMSC (T-hBMSC) in restoring tissue immuno-microenvironment in fulminant hepatic failure (FHF) mice. Methods hBMSC trained with tumor necrosis factor-α and interferon-γ were phenotypically characterized in vitro. FHF mouse models were established in male Balb/c mice via tail vein injection of concanavalin A. The therapeutic potential of T-hBMSC was evaluated through transplantation into FHF mice. Transcriptomic analysis was performed to elucidate the mechanism of liver regeneration post-transplantation of T-hBMSC. Results T-hBMSC with the characteristics of trilineage differentiation potential showed that pro-inflammatory (IL1β, IL8, both p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1757-6512
Relation: https://doaj.org/toc/1757-6512
DOI: 10.1186/s13287-025-04540-x
Access URL: https://doaj.org/article/a41fca5d6f044cce9f8ed22cad78c816
Accession Number: edsdoj.41fca5d6f044cce9f8ed22cad78c816
Database: Directory of Open Access Journals
Description
Abstract:Abstract Background Trained immunity with human bone marrow mesenchymal stem cells (hBMSC) is a promising approach to liver regeneration. This study aimed to clarify the trained-hBMSC (T-hBMSC) in restoring tissue immuno-microenvironment in fulminant hepatic failure (FHF) mice. Methods hBMSC trained with tumor necrosis factor-α and interferon-γ were phenotypically characterized in vitro. FHF mouse models were established in male Balb/c mice via tail vein injection of concanavalin A. The therapeutic potential of T-hBMSC was evaluated through transplantation into FHF mice. Transcriptomic analysis was performed to elucidate the mechanism of liver regeneration post-transplantation of T-hBMSC. Results T-hBMSC with the characteristics of trilineage differentiation potential showed that pro-inflammatory (IL1β, IL8, both p
ISSN:17576512
DOI:10.1186/s13287-025-04540-x