Zobrazit v EDS

Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice

Uloženo v:
Podrobná bibliografie
Název: Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice
Autoři: Bingqi Li, Xiaofei Zeng, Jing Jiang, Qian Zhou, Li Tong, Xi Liang, Jiaojiao Xin, Xi Chen, Xiao Wu, Yuheng Kong, Shiwen Ma, Jinjin Luo, Wei Qiang, Bing Zhu, Xinhua Luo, Jun Li, Dongyan Shi
Zdroj: Stem Cell Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2025)
Informace o vydavateli: BMC, 2025.
Rok vydání: 2025
Sbírka: LCC:Medicine (General)
LCC:Biochemistry
Témata: Trained immunity, Bone marrow mesenchymal stem cells, Immune microenvironment, Fulminant hepatic failure, Medicine (General), R5-920, Biochemistry, QD415-436
Popis: Abstract Background Trained immunity with human bone marrow mesenchymal stem cells (hBMSC) is a promising approach to liver regeneration. This study aimed to clarify the trained-hBMSC (T-hBMSC) in restoring tissue immuno-microenvironment in fulminant hepatic failure (FHF) mice. Methods hBMSC trained with tumor necrosis factor-α and interferon-γ were phenotypically characterized in vitro. FHF mouse models were established in male Balb/c mice via tail vein injection of concanavalin A. The therapeutic potential of T-hBMSC was evaluated through transplantation into FHF mice. Transcriptomic analysis was performed to elucidate the mechanism of liver regeneration post-transplantation of T-hBMSC. Results T-hBMSC with the characteristics of trilineage differentiation potential showed that pro-inflammatory (IL1β, IL8, both p
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 1757-6512
Relation: https://doaj.org/toc/1757-6512
DOI: 10.1186/s13287-025-04540-x
Přístupová URL adresa: https://doaj.org/article/a41fca5d6f044cce9f8ed22cad78c816
Přístupové číslo: edsdoj.41fca5d6f044cce9f8ed22cad78c816
Databáze: Directory of Open Access Journals
Popis
Abstrakt:Abstract Background Trained immunity with human bone marrow mesenchymal stem cells (hBMSC) is a promising approach to liver regeneration. This study aimed to clarify the trained-hBMSC (T-hBMSC) in restoring tissue immuno-microenvironment in fulminant hepatic failure (FHF) mice. Methods hBMSC trained with tumor necrosis factor-α and interferon-γ were phenotypically characterized in vitro. FHF mouse models were established in male Balb/c mice via tail vein injection of concanavalin A. The therapeutic potential of T-hBMSC was evaluated through transplantation into FHF mice. Transcriptomic analysis was performed to elucidate the mechanism of liver regeneration post-transplantation of T-hBMSC. Results T-hBMSC with the characteristics of trilineage differentiation potential showed that pro-inflammatory (IL1β, IL8, both p
ISSN:17576512
DOI:10.1186/s13287-025-04540-x