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Updated techniques and evidence for endoscopic ultrasound‐guided tissue acquisition from solid pancreatic lesions

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Bibliographic Details
Title: Updated techniques and evidence for endoscopic ultrasound‐guided tissue acquisition from solid pancreatic lesions
Authors: Masahiro Itonaga, Reiko Ashida, Masayuki Kitano
Source: DEN Open, Vol 5, Iss 1, Pp n/a-n/a (2025)
Publisher Information: Wiley, 2025.
Publication Year: 2025
Collection: LCC:Diseases of the digestive system. Gastroenterology
Subject Terms: comprehensive genomic profiling, EUS‐TA, EUS‐FNA, needle tract seeding, pancreatic neoplasm, Diseases of the digestive system. Gastroenterology, RC799-869
Description: Abstract Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA), including fine‐needle aspiration (EUS‐FNA) and fine‐needle biopsy (EUS‐FNB), has revolutionized specimen collection from intra‐abdominal organs, especially the pancreas. Advances in personalized medicine and more precise treatment have increased demands to collect specimens with higher cell counts, while preserving tissue structure, leading to the development of EUS‐FNB needles. EUS‐FNB has generally replaced EUS‐FNA as the procedure of choice for EUS‐TA of pancreatic cancer. Various techniques have been tested for their ability to enhance the diagnostic performance of EUS‐TA, including multiple methods of sampling at the time of puncture, on‐site specimen evaluation, and specimen processing. In addition, advances in next‐generation sequencing have made comprehensive genomic profiling of EUS‐TA samples feasible in routine clinical practice. The present review describes updates in EUS‐TA sampling techniques of pancreatic lesions, as well as methods for their evaluation.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2692-4609
Relation: https://doaj.org/toc/2692-4609
DOI: 10.1002/deo2.399
Access URL: https://doaj.org/article/2f36a5ef08cf454e953d79adfc8c8b7d
Accession Number: edsdoj.2f36a5ef08cf454e953d79adfc8c8b7d
Database: Directory of Open Access Journals
Description
Abstract:Abstract Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA), including fine‐needle aspiration (EUS‐FNA) and fine‐needle biopsy (EUS‐FNB), has revolutionized specimen collection from intra‐abdominal organs, especially the pancreas. Advances in personalized medicine and more precise treatment have increased demands to collect specimens with higher cell counts, while preserving tissue structure, leading to the development of EUS‐FNB needles. EUS‐FNB has generally replaced EUS‐FNA as the procedure of choice for EUS‐TA of pancreatic cancer. Various techniques have been tested for their ability to enhance the diagnostic performance of EUS‐TA, including multiple methods of sampling at the time of puncture, on‐site specimen evaluation, and specimen processing. In addition, advances in next‐generation sequencing have made comprehensive genomic profiling of EUS‐TA samples feasible in routine clinical practice. The present review describes updates in EUS‐TA sampling techniques of pancreatic lesions, as well as methods for their evaluation.
ISSN:26924609
DOI:10.1002/deo2.399