THE EFFECTS OF OBESITY ON FEMALE PATIENTS' REPRODUCTIVE FUNCTION IN IN VITRO FERTILIZATION (IVF) PROGRAMS
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| Title: | THE EFFECTS OF OBESITY ON FEMALE PATIENTS' REPRODUCTIVE FUNCTION IN IN VITRO FERTILIZATION (IVF) PROGRAMS |
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| Authors: | Ирина Борисовна Фаткуллина, Альфия Тлешевна Сугурова, Энже Филюсовна Шайхлисламова, Вусала Аладдиновна Садыхова, Танзилла Хамидовна Далаева, Аэллина Александровна Жданова |
| Source: | Мать и дитя в Кузбассе, Vol 26, Iss 1, Pp 78-82 (2025) |
| Publisher Information: | The Publishing House Medicine and Enlightenment, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Pediatrics LCC:Gynecology and obstetrics |
| Subject Terms: | ожирение, экстракорпоральное оплодотворение, оксидативный стресс, качество ооцитов, Pediatrics, RJ1-570, Gynecology and obstetrics, RG1-991 |
| Description: | Due to the multifaceted impact of obesity on women's reproductive function, as well as the outcomes of assisted reproductive technology (ART) programs, there is an urgent need to study the impact of this disease and find ways to solve this problem in women with infertility planning ART programs. This review reflects the literature data showing the mechanisms of the influence of obesity on the negative outcomes of ART programs. To achieve this goal, an electronic search was conducted for literature reviews, randomized clinical trials, and meta-analyses in the Medline, PubMed, Google Scholar, Clinical Trials, and the Cochrane databases until December 2024. In the course of the work carried out, the mechanisms influencing the effectiveness of ART programs in obese patients were identified: adipose tissue is an inflammatory substrate, as a result of chronic inflammation it enhances the synthesis of reactive oxygen species. Reactive oxygen species reduce the quality of oocytes and, consequently, the quality of embryos. This pushes reproductive doctors to pay more attention to pre-pregnancy training of obese patients before ART programs. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Russian |
| ISSN: | 1991-010X 2542-0968 |
| Relation: | https://mednauki.ru/index.php/MD/article/view/1186; https://doaj.org/toc/1991-010X; https://doaj.org/toc/2542-0968 |
| Access URL: | https://doaj.org/article/2396bbff3c6045dba3f0660bdaf7eff4 |
| Accession Number: | edsdoj.2396bbff3c6045dba3f0660bdaf7eff4 |
| Database: | Directory of Open Access Journals |
Nájsť tento článok vo Web of Science | Abstract: | Due to the multifaceted impact of obesity on women's reproductive function, as well as the outcomes of assisted reproductive technology (ART) programs, there is an urgent need to study the impact of this disease and find ways to solve this problem in women with infertility planning ART programs. This review reflects the literature data showing the mechanisms of the influence of obesity on the negative outcomes of ART programs. To achieve this goal, an electronic search was conducted for literature reviews, randomized clinical trials, and meta-analyses in the Medline, PubMed, Google Scholar, Clinical Trials, and the Cochrane databases until December 2024. In the course of the work carried out, the mechanisms influencing the effectiveness of ART programs in obese patients were identified: adipose tissue is an inflammatory substrate, as a result of chronic inflammation it enhances the synthesis of reactive oxygen species. Reactive oxygen species reduce the quality of oocytes and, consequently, the quality of embryos. This pushes reproductive doctors to pay more attention to pre-pregnancy training of obese patients before ART programs. |
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| ISSN: | 1991010X 25420968 |