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Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention

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Název: Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention
Autoři: Alex Jinich-Diamant, Sierra Simpson, Juan P. Zuniga-Hertz, Ramamurthy Chitteti, Jan M. Schilling, Jacqueline A. Bonds, Laura Case, Andrei V. Chernov, Joe Dispenza, Jacqueline Maree, Natalia Esther Amkie Stahl, Michael Licamele, Narin Fazlalipour, Swetha Devulapalli, Leonardo Christov-Moore, Nicco Reggente, Michelle A. Poirier, Tobias Moeller-Bertram, Hemal H. Patel
Zdroj: Communications Biology, Vol 8, Iss 1, Pp 1-19 (2025)
Informace o vydavateli: Nature Portfolio, 2025.
Rok vydání: 2025
Sbírka: LCC:Biology (General)
Témata: Biology (General), QH301-705.5
Popis: Abstract Mind-body interventions offer promising avenues for improving physical and mental health, yet the comprehensive biological effects of increasingly popular mind-body retreat interventions remain poorly understood. The neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals are investigated in an observational study on 20 healthy human participants randomly selected from 561 retreat participants. BOLD fMRI functional connectivity during rest and meditation and whole plasma proteomics, metabolomics, exosome-specific miRNA transcriptomics, and neurite growth and real-time metabolism cellular assays are compared pre- and post-intervention. Meditation decreases functional integration in the default mode (p = 0.00009) and salience networks (p = 0.000003) and decreases whole-brain modularity (p = 0.001). Compared to pre-intervention plasma, post plasma increases in vitro neurite outgrowth (p = 0.01), enhances glycolytic metabolism (p = 0.008), induces upregulation of BDNF (p = 0.001), inflammatory (p = 0.0001), anti-inflammatory (p = 0.03), and endogenous opioid (p = 0.03) pathways, and modulates tryptophan metabolism (p FDR = 0.03) and neurotransmission-associated exosome miRNA transcripts. This intensive non-pharmacological mind-body intervention produces broad short-term neural and plasma-based molecular changes associated with enhanced neuroplasticity, metabolic reprogramming, and modulation of functional cell signaling pathways, highlighting the potential of mind-body techniques to modulate neural circuits and pathways important to health and well-being.
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 2399-3642
Relation: https://doaj.org/toc/2399-3642
DOI: 10.1038/s42003-025-09088-3
Přístupová URL adresa: https://doaj.org/article/1f1b23f2e067445eb06d7659ca93688c
Přístupové číslo: edsdoj.1f1b23f2e067445eb06d7659ca93688c
Databáze: Directory of Open Access Journals
Popis
Abstrakt:Abstract Mind-body interventions offer promising avenues for improving physical and mental health, yet the comprehensive biological effects of increasingly popular mind-body retreat interventions remain poorly understood. The neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals are investigated in an observational study on 20 healthy human participants randomly selected from 561 retreat participants. BOLD fMRI functional connectivity during rest and meditation and whole plasma proteomics, metabolomics, exosome-specific miRNA transcriptomics, and neurite growth and real-time metabolism cellular assays are compared pre- and post-intervention. Meditation decreases functional integration in the default mode (p = 0.00009) and salience networks (p = 0.000003) and decreases whole-brain modularity (p = 0.001). Compared to pre-intervention plasma, post plasma increases in vitro neurite outgrowth (p = 0.01), enhances glycolytic metabolism (p = 0.008), induces upregulation of BDNF (p = 0.001), inflammatory (p = 0.0001), anti-inflammatory (p = 0.03), and endogenous opioid (p = 0.03) pathways, and modulates tryptophan metabolism (p FDR = 0.03) and neurotransmission-associated exosome miRNA transcripts. This intensive non-pharmacological mind-body intervention produces broad short-term neural and plasma-based molecular changes associated with enhanced neuroplasticity, metabolic reprogramming, and modulation of functional cell signaling pathways, highlighting the potential of mind-body techniques to modulate neural circuits and pathways important to health and well-being.
ISSN:23993642
DOI:10.1038/s42003-025-09088-3