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Gamma-glutamyltransferase and the survival of hepatocellular carcinoma patients after transarterial chemoembolization: a meta‑analysis and systematic review

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Název: Gamma-glutamyltransferase and the survival of hepatocellular carcinoma patients after transarterial chemoembolization: a meta‑analysis and systematic review
Autoři: Zixin Huang, Manli Zhou, Sisi Feng, Xiaomin Xiao, Baiyun Zhong
Zdroj: BMC Gastroenterology, Vol 25, Iss 1, Pp 1-12 (2025)
Informace o vydavateli: BMC, 2025.
Rok vydání: 2025
Sbírka: LCC:Diseases of the digestive system. Gastroenterology
Témata: Gamma-glutamyltransferase, Hepatocellular carcinoma, Prognostic biomarker, Transarterial chemoembolization, Meta-analysis, Diseases of the digestive system. Gastroenterology, RC799-869
Popis: Abstract Objective Plentiful studies have reported that preoperative gamma-glutamyltransferase (GGT) had a strong relationship with the prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). Nevertheless, due to the small sample size and contradictory conclusions, the predictive function remains indefinite. To investigate the relationship between pretreatment GGT value and clinical outcomes in HCC patients undergoing TACE, a meta-analysis including 10 articles was constructed. Method Studies were searched in PubMed, Embase, Web of Science, Cochrane Library, CNKI, and Wanfang database. Pooled Hazard Ratio (HR) or Odd Ratio (OR) with its 95% confidence intervals was calculated to evaluate the prognostic value of pretreatment GGT in HCC patients undergoing TACE. Result Ten studies with 3274 patients were included in our meta-analysis. The pooled results show that elevated pretreatment GGT has a close relationship to poorer OS (HR 1.72; 95%CI: 1.48–2.01, P
Druh dokumentu: article
Popis souboru: electronic resource
Jazyk: English
ISSN: 1471-230X
Relation: https://doaj.org/toc/1471-230X
DOI: 10.1186/s12876-025-04321-z
Přístupová URL adresa: https://doaj.org/article/0d096b8e5ffa4c85a4bfd6fbf30ff6e5
Přístupové číslo: edsdoj.0d096b8e5ffa4c85a4bfd6fbf30ff6e5
Databáze: Directory of Open Access Journals
Popis
Abstrakt:Abstract Objective Plentiful studies have reported that preoperative gamma-glutamyltransferase (GGT) had a strong relationship with the prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). Nevertheless, due to the small sample size and contradictory conclusions, the predictive function remains indefinite. To investigate the relationship between pretreatment GGT value and clinical outcomes in HCC patients undergoing TACE, a meta-analysis including 10 articles was constructed. Method Studies were searched in PubMed, Embase, Web of Science, Cochrane Library, CNKI, and Wanfang database. Pooled Hazard Ratio (HR) or Odd Ratio (OR) with its 95% confidence intervals was calculated to evaluate the prognostic value of pretreatment GGT in HCC patients undergoing TACE. Result Ten studies with 3274 patients were included in our meta-analysis. The pooled results show that elevated pretreatment GGT has a close relationship to poorer OS (HR 1.72; 95%CI: 1.48–2.01, P
ISSN:1471230X
DOI:10.1186/s12876-025-04321-z